Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT
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DOI: 10.1371/journal.pbio.3001616
Abstract: Polymorphisms in the Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene and the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene alter the malaria parasite’s susceptibility to most of the current antimalarial drugs. However, the precise… read more here.
Keywords: lumefantrine mefloquine; multidrug resistance; pfmdr1 pfcrt; resistance ... See more keywords