Proteomic identification of intracellular vesicle trafficking and protein glycosylation requirements for lumen inflation in Ciona notochord
Sign Up to like & getrecommendations! Published in 2023 at "PROTEOMICS"
DOI: 10.1002/pmic.202200460
Abstract: Lumen formation and inflation are crucial steps for tubular organ morphogenesis, yet the underling mechanism remains largely unrevealed. Here, we applied 4D proteomics to screen the lumenogenesis‐related proteins and revealed the biological pathways potentially that… read more here.
Keywords: lumen inflation; glycosylation; vesicle trafficking; lumen formation ... See more keywords
Vinculin controls endothelial cell junction dynamics during vascular lumen formation.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110658
Abstract: Blood vessel morphogenesis is driven by coordinated endothelial cell behaviors. Active remodeling of cell-cell junctions promotes cellular plasticity while preserving vascular integrity. Here, we analyze the dynamics of endothelial adherens junctions during lumen formation in… read more here.
Keywords: junctional fingers; endothelial cell; vinculin; cell ... See more keywords
Autophagy, not apoptosis, plays a role in lumen formation of eccrine gland organoids
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000001936
Abstract: Abstract Background: Sweat secreted by eccrine sweat glands is transported to the skin surface through the lumen. The eccrine sweat gland develops from the initial solid bud to the final gland structure with a lumen,… read more here.
Keywords: apoptosis; eccrine gland; formation eccrine; gland ... See more keywords
ELMOD3-Rab1A-Flotillin2 cascade regulates lumen formation via vesicle trafficking in Ciona notochord
Sign Up to like & getrecommendations! Published in 2023 at "Open Biology"
DOI: 10.1098/rsob.220367
Abstract: Lumen development is a crucial phase in tubulogenesis, although its molecular mechanisms are largely unknown. In this study, we discovered an ELMO domain-containing 3 (ELMOD3), which belongs to ADP-ribosylation factor GTPase-activating protein family, was necessary… read more here.
Keywords: elmod3; vesicle trafficking; lumen formation; formation ... See more keywords
The Effect and Mechanism of TRPC1, 3, and 6 on the Proliferation, Migration, and Lumen Formation of Retinal Vascular Endothelial Cells Induced by High Glucose
Sign Up to like & getrecommendations! Published in 2020 at "Ophthalmic Research"
DOI: 10.1159/000503724
Abstract: Objective: Transient receptor potential canonical (TRPC) channels are involved in neovascularization repairing after vascular injury in many tissues. However, whether TRPCs play a regulatory role in the development of diabetic retinopathy (DR) has rarely been… read more here.
Keywords: proliferation migration; migration lumen; expression; lumen formation ... See more keywords
EFA6 proteins regulate lumen formation through α-actinin 1
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.209361
Abstract: ABSTRACT A key step of epithelial morphogenesis is the creation of the lumen. Luminogenesis by hollowing proceeds through the fusion of apical vesicles at cell–cell contacts. The small nascent lumens grow through extension, coalescence and… read more here.
Keywords: lumen formation; proteins regulate; regulate lumen; efa6 proteins ... See more keywords
Quantitative modeling identifies critical cell mechanics driving bile duct lumen formation
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1009653
Abstract: Biliary ducts collect bile from liver lobules, the smallest functional and anatomical units of liver, and carry it to the gallbladder. Disruptions in this process caused by defective embryonic development, or through ductal reaction in… read more here.
Keywords: bile duct; mechanics; duct lumen; cell ... See more keywords
3D Organoid Culture From Adult Salivary Gland Tissues as an ex vivo Modeling of Salivary Gland Morphogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.698292
Abstract: Lumen formation of salivary glands has been investigated using in vivo or ex vivo rudiment culture models. In this study, we used a three-dimensional (3D) salivary gland organoid culture system and demonstrated that lumen formation… read more here.
Keywords: lumen formation; gland morphogenesis; salivary gland; organoid culture ... See more keywords
Modelling of Epithelial Growth, Fission and Lumen Formation During Embryonic Thyroid Development: A Combination of Computational and Experimental Approaches
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.655862
Abstract: Organogenesis is the phase of embryonic development leading to the formation of fully functional organs. In the case of the thyroid, organogenesis starts from the endoderm and generates a multitude of closely packed independent spherical… read more here.
Keywords: lumen formation; fission; experimental approaches; growth ... See more keywords