The Analysis of Plasma Proteomics for Luminal A Breast Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.70470
Abstract: Breast cancer is the prevailing malignancy among women, exhibiting a discernible escalation in incidence within our nation; hormone receptor‐positive (HR+) human epidermal growth factor receptor 2‐negative (HER2−) breast cancer is the most common subtype. In… read more here.
Keywords: cancer; luminal breast; breast cancer; plasma proteomics ... See more keywords
The cytokine profile correlates with less tumor-infiltrating lymphocytes in luminal A breast cancer
Sign Up to like & getrecommendations! Published in 2024 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-024-07492-7
Abstract: Tumor-infiltrating lymphocyte (TIL) levels are prognostic and predictive factors for breast cancer. Unlike other subtypes, most luminal A breast cancers are immune deserts; however, the underlying mechanisms are poorly understood. Immune-related cytokines, chemokines, and growth… read more here.
Keywords: til levels; breast cancer; luminal breast; tumor infiltrating ... See more keywords
Inhibition of BTF3 sensitizes luminal breast cancer cells to PI3Kα inhibition through the transcriptional regulation of ERα.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.09.030
Abstract: Selective phosphatidylinositol 3 kinase (PI3K) inhibitors are being actively tested in clinical trials for ERα-positive (ER+) breast cancer due to the presence of activating PIK3CA mutations. However, recent studies have revealed that increased ERα transcriptional… read more here.
Keywords: breast; inhibition; luminal breast; breast cancer ... See more keywords
MCM2: An alternative to Ki-67 for measuring breast cancer cell proliferation
Sign Up to like & getrecommendations! Published in 2017 at "Modern Pathology"
DOI: 10.1038/modpathol.2016.231
Abstract: Breast cancer is a heterogeneous disease comprising a diversity of tumor subtypes that manifest themselves in a wide variety of clinical, pathological, and molecular features. One important subset, luminal breast cancers, comprises two clinically distinct… read more here.
Keywords: breast; luminal breast; proliferation; breast cancer ... See more keywords
Protein co-expression networks identified from HOT lesions of ER+HER2-Ki-67high luminal breast carcinomas.
Sign Up to like & getrecommendations! Published in 2021 at "Scientific reports"
DOI: 10.1038/s41598-021-81509-9
Abstract: Patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative/Ki-67-high (ER+HER2-Ki-67high) luminal breast cancer have a worse prognosis and do not respond to hormonal treatment and chemotherapy. This study sought to identify disease-related protein networks significantly… read more here.
Keywords: breast; analysis; luminal breast; 67high luminal ... See more keywords
WWP1 targeting PTEN for polyubiquitination to promote bone metastasis of luminal breast cancer
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-81541-5
Abstract: Luminal breast cancer exhibits a high incidence of bone recurrence when metastasizing to distant organs. The mechanisms underlying the organotropism of luminal breast cancer cells remain unclear. In this study, we aimed to determine the… read more here.
Keywords: cancer; luminal breast; cancer cells; breast cancer ... See more keywords
Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in luminal A breast cancer
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2311854121
Abstract: Significance Collecting time-course breast cancer biopsies is difficult. As a result, the influence of daily rhythms on breast tumor biology remains a mystery and physicians cannot personalize the timing of cancer therapies. We used machine… read more here.
Keywords: cancer; luminal breast; breast cancer; breast ... See more keywords
Type IV collagen α5 chain promotes luminal breast cancer progression through c-Myc-driven glycolysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjac068
Abstract: ABSTRACT Cancer cell metabolism reprogramming is one of the hallmarks of cancer. Cancer cells preferentially utilize aerobic glycolysis, which is regulated by activated oncogenes and the tumor microenvironment. Extracellular matrix (ECM) in the tumor microenvironment,… read more here.
Keywords: luminal breast; breast cancer; glycolysis; type ... See more keywords
Luminal A versus luminal B breast cancer: MammaTyper mRNA versus immunohistochemical subtyping with an emphasis on standardised Ki67 labelling‐based or mitotic activity index‐based proliferation assessment
Sign Up to like & getrecommendations! Published in 2019 at "Histopathology"
DOI: 10.1111/his.14048
Abstract: Proliferation assessment by the use of Ki67 is a crucial component in intrinsic subtyping of luminal breast cancers (BCs), but suffers from variability between laboratories, observers, and methods. MammaTyper is a quantitative molecular tool that… read more here.
Keywords: proliferation assessment; versus luminal; luminal breast; proliferation ... See more keywords
Identification of Crucial lncRNAs for Luminal A Breast Cancer through RNA Sequencing
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Endocrinology"
DOI: 10.1155/2022/6577942
Abstract: Background The growing body of evidence indicates aberrant expression of long noncoding RNAs (lncRNAs) in breast cancer. Nevertheless, a few studies have focused on identifying key lncRNAs for patients with luminal A breast cancer. In… read more here.
Keywords: luminal breast; breast cancer; breast; rna sequencing ... See more keywords
TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-3133
Abstract: Breast cancer subtypes and their phenotypes parallel different stages of the mammary epithelial cell developmental hierarchy. Discovering mechanisms that control lineage identity could provide novel avenues for mitigating disease progression. Here we report that the… read more here.
Keywords: tle3; luminal breast; breast; breast cancer ... See more keywords