Inhibition of BTF3 sensitizes luminal breast cancer cells to PI3Kα inhibition through the transcriptional regulation of ERα.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.09.030
Abstract: Selective phosphatidylinositol 3 kinase (PI3K) inhibitors are being actively tested in clinical trials for ERα-positive (ER+) breast cancer due to the presence of activating PIK3CA mutations. However, recent studies have revealed that increased ERα transcriptional… read more here.
Keywords: breast; inhibition; luminal breast; breast cancer ... See more keywords
MCM2: An alternative to Ki-67 for measuring breast cancer cell proliferation
Sign Up to like & getrecommendations! Published in 2017 at "Modern Pathology"
DOI: 10.1038/modpathol.2016.231
Abstract: Breast cancer is a heterogeneous disease comprising a diversity of tumor subtypes that manifest themselves in a wide variety of clinical, pathological, and molecular features. One important subset, luminal breast cancers, comprises two clinically distinct… read more here.
Keywords: breast; luminal breast; proliferation; breast cancer ... See more keywords
Protein co-expression networks identified from HOT lesions of ER+HER2-Ki-67high luminal breast carcinomas.
Sign Up to like & getrecommendations! Published in 2021 at "Scientific reports"
DOI: 10.1038/s41598-021-81509-9
Abstract: Patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative/Ki-67-high (ER+HER2-Ki-67high) luminal breast cancer have a worse prognosis and do not respond to hormonal treatment and chemotherapy. This study sought to identify disease-related protein networks significantly… read more here.
Keywords: breast; analysis; luminal breast; 67high luminal ... See more keywords
Type IV collagen α5 chain promotes luminal breast cancer progression through c-Myc-driven glycolysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjac068
Abstract: ABSTRACT Cancer cell metabolism reprogramming is one of the hallmarks of cancer. Cancer cells preferentially utilize aerobic glycolysis, which is regulated by activated oncogenes and the tumor microenvironment. Extracellular matrix (ECM) in the tumor microenvironment,… read more here.
Keywords: luminal breast; breast cancer; glycolysis; type ... See more keywords
Luminal A versus luminal B breast cancer: MammaTyper mRNA versus immunohistochemical subtyping with an emphasis on standardised Ki67 labelling‐based or mitotic activity index‐based proliferation assessment
Sign Up to like & getrecommendations! Published in 2019 at "Histopathology"
DOI: 10.1111/his.14048
Abstract: Proliferation assessment by the use of Ki67 is a crucial component in intrinsic subtyping of luminal breast cancers (BCs), but suffers from variability between laboratories, observers, and methods. MammaTyper is a quantitative molecular tool that… read more here.
Keywords: proliferation assessment; versus luminal; luminal breast; proliferation ... See more keywords
Identification of Crucial lncRNAs for Luminal A Breast Cancer through RNA Sequencing
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Endocrinology"
DOI: 10.1155/2022/6577942
Abstract: Background The growing body of evidence indicates aberrant expression of long noncoding RNAs (lncRNAs) in breast cancer. Nevertheless, a few studies have focused on identifying key lncRNAs for patients with luminal A breast cancer. In… read more here.
Keywords: luminal breast; breast cancer; breast; rna sequencing ... See more keywords
TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-3133
Abstract: Breast cancer subtypes and their phenotypes parallel different stages of the mammary epithelial cell developmental hierarchy. Discovering mechanisms that control lineage identity could provide novel avenues for mitigating disease progression. Here we report that the… read more here.
Keywords: tle3; luminal breast; breast; breast cancer ... See more keywords
Abstract 3994: Differential regulation of hormone receptors and Ki67 in luminal breast carcinomas and tumor-adjacent mammary glands by mifepristone treatment
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3994
Abstract: Since antiprogestins inhibit the growth of preclinical mammary tumor models expressing higher levels of progesterone receptor (PR) isoform A (PRA) than isoform B (PRB), we designed a window-of-opportunity trial (MIPRA; NCT02651844) to study the benefits… read more here.
Keywords: luminal breast; expression; breast carcinomas; mammary glands ... See more keywords
Abstract PS6-51: Identification of a low-risk luminal breast cancer cohort that may not benefit from multi-gene testing
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs20-ps6-51
Abstract: Purpose: Dutch clinical risk criteria (low-risk definition: age > 35 years and (grade 1 with tumor ≤3cm, grade 2 with tumor ≤2cm, or grade 3 with tumor ≤1cm) have been used to stratify the benefit… read more here.
Keywords: low risk; cancer; risk; breast cancer ... See more keywords
Histology of Luminal Breast Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Breast Care"
DOI: 10.1159/000509025
Abstract: Background: Invasive breast cancer (IBC) can be categorized into prognostic and predictive molecular subtypes (including luminal breast cancer) using gene expression profiling. Luminal IBC comprises a variety of histological subtypes with varying clinical and pathological… read more here.
Keywords: breast; luminal breast; breast cancer; expression ... See more keywords
Genomic Signatures in Luminal Breast Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Breast Care"
DOI: 10.1159/000509846
Abstract: Background: Breast cancer is a very heterogeneous disease and luminal breast carcinomas represent the hormone receptor-positive tumors among all breast cancer subtypes. In this context, multigene signatures were developed to gain further prognostic and predictive… read more here.
Keywords: signatures luminal; breast; luminal breast; breast cancer ... See more keywords