Luminal addition of non-permeant Eu3+ interferes with luminal Ca2+ regulation of the cardiac ryanodine receptor.
Sign Up to like & getrecommendations! Published in 2019 at "Bioelectrochemistry"
DOI: 10.1016/j.bioelechem.2019.107449
Abstract: Dysregulation of the cardiac ryanodine receptor (RYR2) by luminal Ca2+ has been implicated in a life-threatening, stress-induced arrhythmogenic disease. The mechanism of luminal Ca2+-mediated RYR2 regulation is under debate, and it has been attributed to… read more here.
Keywords: mechanism; luminal ca2; eu3; cardiac ryanodine ... See more keywords
ER-luminal [Ca2+] regulation of InsP3 receptor gating mediated by an ER-luminal peripheral Ca2+-binding protein
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.53531
Abstract: Modulating cytoplasmic Ca2+ concentration ([Ca2+]i) by endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptor (InsP3R) Ca2+-release channels is a universal signaling pathway that regulates numerous cell-physiological processes. Whereas much is known regarding regulation of InsP3R activity by… read more here.
Keywords: luminal ca2; insp3r; ca2 binding; regulation ... See more keywords