LncRNA ZFPM2‐AS1 promotes lung adenocarcinoma progression by interacting with UPF1 to destabilize ZFPM2
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12631
Abstract: Lung adenocarcinoma (LUAD), a histological subclass of non‐small‐cell lung cancer, is globally the leading cause of cancer‐related deaths. Long noncoding RNAs (lncRNAs) are emerging as cancer regulators. Zinc finger protein multitype 2 antisense RNA 1… read more here.
Keywords: lung adenocarcinoma; zfpm2; zfpm2 as1; cancer ... See more keywords
Identification and validation of novel DNA methylation markers for early diagnosis of lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12767
Abstract: Lung cancer has the highest mortality of all cancers worldwide. Epigenetic alterations have emerged as potential biomarkers for early diagnosis of various cancer tissue types. To identify methylation markers for early diagnosis of lung adenocarcinoma,… read more here.
Keywords: lung adenocarcinoma; methylation; dna methylation; methylation markers ... See more keywords
Hypoxia-induced miR-210-3p expression in lung adenocarcinoma potentiates tumor development by regulating CCL2-mediated monocyte infiltration.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13260
Abstract: In most cancers, tumor hypoxia downregulates the expression of C-C motif chemokine 2 (CCL2), and this downregulation has been implicated in monocyte infiltration and tumor progression; however, the molecular mechanism is yet not clear. We… read more here.
Keywords: mir 210; lung adenocarcinoma; ccl2; expression ... See more keywords
MFN2 deficiency affects calcium homeostasis in lung adenocarcinoma cells via downregulation of UCP4.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13591
Abstract: Mitofusin‐2 (MFN2) is a transmembrane GTPase that regulates mitochondrial fusion and thereby modulates mitochondrial function. However, the role of MFN2 in lung adenocarcinoma remains controversial. Here, we investigated the effect of MFN2 regulation on mitochondria… read more here.
Keywords: mfn2; mfn2 ucp4; lung adenocarcinoma; calcium homeostasis ... See more keywords
Integrative Serum Metabolic Fingerprints Based Multi‐Modal Platforms for Lung Adenocarcinoma Early Detection and Pulmonary Nodule Classification
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DOI: 10.1002/advs.202203786
Abstract: Identification of novel non‐invasive biomarkers is critical for the early diagnosis of lung adenocarcinoma (LUAD), especially for the accurate classification of pulmonary nodule. Here, a multiplexed assay is developed on an optimized nanoparticle‐based laser desorption/ionization… read more here.
Keywords: lung adenocarcinoma; pulmonary nodule; classification; metabolic fingerprints ... See more keywords
Targeting GSTP1 as Therapeutic Strategy against Lung Adenocarcinoma Stemness and Resistance to Tyrosine Kinase Inhibitors
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DOI: 10.1002/advs.202205262
Abstract: Glutathione S‐transferase pi (GSTP1), a phase II detoxification enzyme, is known to be overexpressed and mediates chemotherapeutic resistance in lung cancer. However, whether GSTP1 supports cancer stem cells (CSCs) and the underlying mechanisms in lung… read more here.
Keywords: lung adenocarcinoma; lung; tyrosine kinase; resistance ... See more keywords
Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer communications"
DOI: 10.1002/cac2.12275
Abstract: BACKGROUND Resistance to ferroptosis, a regulated cell death caused by iron-dependent excessive accumulation of lipid peroxides, has recently been linked to lung adenocarcinoma (LUAD). Intracellular antioxidant systems are required for protection against ferroptosis. The purpose… read more here.
Keywords: lung; ferroptosis; luad; cell ... See more keywords
Ketamine induces apoptosis in lung adenocarcinoma cells by regulating the expression of CD69
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1288
Abstract: Ketamine, an anesthetic, analgesic, or sedative, is widely used for the treatment of cancer pain. Recently, ketamine has been also reported to be tumor repressor for inhibiting proliferation, invasion, and migration, and inducing apoptosis in… read more here.
Keywords: lung adenocarcinoma; apoptosis lung; cd69; apoptosis ... See more keywords
MiR‐21 improves invasion and migration of drug‐resistant lung adenocarcinoma cancer cell and transformation of EMT through targeting HBP1
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1294
Abstract: This study was aimed at the investigation of the effects of miR‐21 on drug resistance, invasion, migration, and epithelial–mesenchymal transition (EMT) of lung adenocarcinoma cells and the related molecular mechanisms. Cell viability of A549 cell… read more here.
Keywords: lung adenocarcinoma; migration; hbp1; drug ... See more keywords
Differentially expressed and survival‐related proteins of lung adenocarcinoma with bone metastasis
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1363
Abstract: Despite recent advances in targeted and immune‐based therapies, the poor prognosis of lung adenocarcinoma (LUAD) with bone metastasis (BM) remains a challenge. First, two‐dimensional gel electrophoresis (2‐DE) was used to identify proteins that were differentially… read more here.
Keywords: lung adenocarcinoma; differentially expressed; bone metastasis; survival ... See more keywords
Aberrant CpG‐methylation affects genes expression predicting survival in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1834
Abstract: Lung adenocarcinoma (LUAD) is a common diagnosed disease with high‐mortality rate, and its prognostic implications are under discovered. DNA methylation aberrations are not only an important event for dysregulation of gene expression during tumorigenesis but… read more here.
Keywords: lung adenocarcinoma; methylation; expression; luad ... See more keywords