Monitoring practices of chronic lung allograft dysfunction in pediatric lung transplantation
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.26187
Abstract: Chronic lung allograft dysfunction (CLAD) continues to negatively impact the survival of pediatric lung transplant (LTx) recipients. Current consensus guidelines are adult‐focused. We sought to examine CLAD detection and monitoring practices at pediatric LTx programs. read more here.
Keywords: allograft dysfunction; lung; monitoring practices; pediatric lung ... See more keywords
The role of donor-derived exosomes in lung allograft rejection.
Sign Up to like & getrecommendations! Published in 2019 at "Human immunology"
DOI: 10.1016/j.humimm.2019.03.012
Abstract: Lung transplant recipients (LTxRs) with acute or chronic rejection release circulating exosomes that mostly originate from donor lung tissue and express mismatched human leucocyte antigens (HLA) and lung-associated self-antigens (SAgs), Collagen-V and K alpha 1… read more here.
Keywords: rejection; lung allograft; donor; lung sags ... See more keywords
Azithromycin Fails to Prevent Accelerated Airway Obliteration in T-bet-/- Mouse Lung Allograft Recipients.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2018.02.070
Abstract: BACKGROUND Cellular and molecular mechanisms of acute and chronic lung allograft rejection have yet to be clearly defined, and obliterative bronchiolitis (OB) remains the primary limitation to survival in lung transplant recipients (LTRs). We have… read more here.
Keywords: azithromycin fails; bet; lung allograft; allograft ... See more keywords
Antithymocyte Globulin Treatment for Chronic Lung Allograft Dysfunction in Lung Transplant Recipients: Experience From a National Reference Transplant Center.
Sign Up to like & getrecommendations! Published in 2021 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2021.08.039
Abstract: BACKGROUND Chronic lung allograft dysfunction (CLAD) is the leading cause of mortality after the first year of transplantation and treatments can have little impact on CLAD progression in some cases. The objective of this study… read more here.
Keywords: treatment; lung allograft; lung transplant; chronic lung ... See more keywords
Chronic Lung Allograft Dysfunction: Evolving Concepts and Therapies.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in respiratory and critical care medicine"
DOI: 10.1055/s-0041-1729175
Abstract: The primary factor that limits long-term survival after lung transplantation is chronic lung allograft dysfunction (CLAD). CLAD also impairs quality of life and increases the costs of medical care. Our understanding of CLAD continues to… read more here.
Keywords: medicine; clad; lung allograft; allograft dysfunction ... See more keywords
The healthcare resource utilization and costs of chronic lung allograft dysfunction following lung transplantation in patients with commercial insurance in the United States
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Economics"
DOI: 10.1080/13696998.2022.2071065
Abstract: Abstract Aims Chronic lung allograft dysfunction (CLAD), a common complication of lung transplantation, is the leading cause of death for lung transplant recipients. While data on lung transplant costs are available, the impact of CLAD… read more here.
Keywords: lung transplantation; diagnosis; lung; transplantation ... See more keywords
Infection from Lung Allograft Donors in Lung Transplantation
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/01.tp.0000543895.08954.51
Abstract: Introduction Infection was the leading cause of perioperative death after lung transplantation. Some infections were due to donor-to-host transmission. The Objective of these study was to evaluate the incidence and etiology of bacterial and fungal… read more here.
Keywords: etiology; infection; lung allograft; lung transplantation ... See more keywords
Chronic lung allograft dysfunction and restrictive allograft syndrome: are phenotypes robust and helpful?
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Organ Transplantation"
DOI: 10.1097/mot.0000000000000962
Abstract: Purpose of review New chronic lung allograft dysfunction (CLAD) consensus documents were published in 2019, defining four phenotypes; bronchiolitis obliterans syndrome, restrictive allograft syndrome, mixed and undefined. Clearly, validation of these guidelines in a real… read more here.
Keywords: restrictive allograft; allograft dysfunction; lung; allograft ... See more keywords
NKG2C Natural Killer Cells in Bronchoalveolar Lavage Are Associated With Cytomegalovirus Viremia and Poor Outcomes in Lung Allograft Recipients
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DOI: 10.1097/tp.0000000000002450
Abstract: Background. Cytomegalovirus (CMV) infection is a risk factor for chronic lung allograft dysfunction (CLAD), which limits survival in lung allograft recipients. Natural killer (NK) cells that express the NKG2C receptor mediate CMV-specific immune responses. We… read more here.
Keywords: lung allograft; cmv; viremia; natural killer ... See more keywords
Biomarkers for Chronic Lung Allograft Dysfunction: Ready for Prime Time?
Sign Up to like & getrecommendations! Published in 2022 at "Transplantation"
DOI: 10.1097/tp.0000000000004270
Abstract: Chronic lung allograft dysfunction (CLAD) remains a major hurdle impairing lung transplant outcome. Parallel to the better clinical identification and characterization of CLAD and CLAD phenotypes, there is an increasing urge to find adequate biomarkers… read more here.
Keywords: lung; lung allograft; chronic lung; allograft dysfunction ... See more keywords
Assessment of dd-cfDNA Levels in Clinically Stable Lung Allograft Recipients Beyond the Initial 2 y Posttransplant
Sign Up to like & getrecommendations! Published in 2022 at "Transplantation Direct"
DOI: 10.1097/txd.0000000000001411
Abstract: Background. Donor-derived cell-free DNA (dd-cfDNA) is a useful biomarker for the diagnosis of acute allograft injury within the first 1 to 2 y after lung transplant, but its utility for diagnosing chronic lung allograft dysfunction… read more here.
Keywords: cfdna levels; clinically stable; cfdna; lung ... See more keywords