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   Articles with "lung axis" as a keyword



The synergistic link between sonic hedgehog signaling pathway and gut–lung axis: Its influential role toward chronic obstructive pulmonary disease progression

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recommendations! Published in 2025 at "Developmental Dynamics"

DOI: 10.1002/dvdy.70006

Abstract: Sonic Hedgehog (SHH) is an evolutionarily conserved signaling pathway essential for embryonic development, tissue homeostasis, and tumorigenesis. Aberrant activation of the SHH pathway induces various types of cancer and different types of immune dysregulation. SHH… read more here.

Keywords: lung; shh; lung axis; gut lung ... See more keywords

Association of SARS-CoV-2 and Polypharmacy with Gut–Lung Axis: From Pathogenesis to Treatment

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recommendations! Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.2c02524

Abstract: SARS-CoV-2 is a novel infectious contagion leading to COVID-19 disease. The virus has affected the lives of millions of people across the globe with a high mortality rate. It predominantly affects the lung (respiratory system),… read more here.

Keywords: gut lung; polypharmacy; lung; lung axis ... See more keywords
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Every breath you take: Impacts of environmental dust exposure on intestinal barrier function–from the gut-lung axis to COVID-19

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recommendations! Published in 2021 at "American Journal of Physiology - Gastrointestinal and Liver Physiology"

DOI: 10.1152/ajpgi.00423.2020

Abstract: As countries continue to industrialize, major cities experience diminished air quality, while rural populations also experience poor air quality from sources such as agricultural operations. These exposures to environmental pollution from both rural and populated/industrialized… read more here.

Keywords: lung axis; covid; physiology; gut lung ... See more keywords

Insights on the Gut-Mesentery-Lung Axis in Pulmonary Arterial Hypertension: A Poorly Investigated Crossroad

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recommendations! Published in 2022 at "Arteriosclerosis, Thrombosis, and Vascular Biology"

DOI: 10.1161/atvbaha.121.316236

Abstract: Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by the hyperproliferation of vascular cells, including smooth muscle and endothelial cells. Hyperproliferative cells eventually obstruct the lung vasculature, leading to irreversible lesions that collectively drive… read more here.

Keywords: arterial hypertension; mesentery lung; gut mesentery; lung axis ... See more keywords

The Bidirectional Gut-Lung Axis in COPD.

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recommendations! Published in 2023 at "American journal of respiratory and critical care medicine"

DOI: 10.1164/rccm.202206-1066tr

Abstract: Epidemiological studies indicate that chronic obstructive pulmonary disease (COPD) is associated with the incidence of changes in intestinal health. Cigarette smoking, as one of the major causes of COPD, can have an impact on the… read more here.

Keywords: lung axis; copd; bidirectional gut; gut lung ... See more keywords

The gut-lung axis and microbiome dysbiosis in non-tuberculous mycobacterial infections: immune mechanisms, clinical implications, and therapeutic frontiers

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recommendations! Published in 2025 at "Gut Pathogens"

DOI: 10.1186/s13099-025-00718-z

Abstract: Non-tuberculous mycobacteria (NTM) are emerging pathogens of global concern, particularly in regions with declining tuberculosis rates. This review synthesizes current evidence on the epidemiology, immune pathogenesis, and microbiome interactions underlying NTM infections. The rising incidence… read more here.

Keywords: gut lung; lung axis; non tuberculous; microbiome dysbiosis ... See more keywords

The Ability of Resveratrol to Attenuate Ovalbumin-Mediated Allergic Asthma Is Associated With Changes in Microbiota Involving the Gut-Lung Axis, Enhanced Barrier Function and Decreased Inflammation in the Lungs

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.805770

Abstract: Asthma is a chronic respiratory disease highly prevalent worldwide. Recent studies have suggested a role for microbiome-associated gut–lung axis in asthma development. In the current study, we investigated if Resveratrol (RES), a plant-based polyphenol, can… read more here.

Keywords: attenuate ovalbumin; gut lung; allergic asthma; lung ... See more keywords

Advances in gut-lung axis research: clinical perspectives on pneumonia prevention and treatment

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recommendations! Published in 2025 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2025.1576141

Abstract: In recent years, the study of the interaction between gut microbiota and distant organs such as the heart, lungs, brain, and liver has become a hot topic in the field of gut microbiology. With a… read more here.

Keywords: gut microbiota; lung axis; gut; prevention ... See more keywords

Lung cancer and the Gut-microbiota-lung Axis: emerging evidence and potential clinical implications

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recommendations! Published in 2025 at "Frontiers in Medicine"

DOI: 10.3389/fmed.2025.1655780

Abstract: Lung cancer remains the leading cause of cancer-related deaths globally, with a 5-years survival rate of only around 20%. Merging cohort and Mendelian-randomization studies indicate that gut dysbiosis is associated with—though not yet proven to… read more here.

Keywords: cancer; lung; lung cancer; lung axis ... See more keywords

Bypassing the Gut–Lung Axis via Microbial Metabolites: Implications for Chronic Respiratory Diseases

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recommendations! Published in 2022 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2022.857418

Abstract: The gut microbiome engages in constant interactions with the immune system, laying down the fundamentals of what we perceive as health or disease. The gut microbiota acts locally in the intestines and distally in other… read more here.

Keywords: gut; gut lung; lung axis; chronic respiratory ... See more keywords

COPD and Gut–Lung Axis: How Microbiota and Host Inflammasome Influence COPD and Related Therapeutics

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recommendations! Published in 2022 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2022.868086

Abstract: The exact pathogenesis of chronic obstructive pulmonary disease (COPD) remains largely unknown. While current management strategies are effective at stabilizing the disease or relief the symptoms, new approaches are required to target underlying disease process… read more here.

Keywords: copd; microbiota; gut lung; lung ... See more keywords