Protective role of AKBA against benzo(a)pyrene‐induced lung carcinogenesis by modulating biotransformation enzymes and oxidative stress
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23072
Abstract: The present study was designed to explore the chemopreventive potential of 3‐acetyl‐11‐keto‐β‐boswellic acid (AKBA) during the initiation and promotion stage of lung carcinogenesis induced by benzo(a)pyrene (BaP) in female Sprague Dawley rats. BaP was administered… read more here.
Keywords: lung carcinogenesis; bap; oxidative stress; benzo pyrene ... See more keywords
Anticancer Effect of Rosiglitazone, a PPAR-γ Agonist against Diethylnitrosamine-Induced Lung Carcinogenesis
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DOI: 10.1021/acsomega.9b04357
Abstract: Multiple effects on cancer cells are exerted by the peroxisome proliferator-activated receptor γ (PPAR-γ). Recent studies have shown that rosiglitazone, a synthetic PPAR-γ ligand, inhibits the growth of cells. This research was designed to assess… read more here.
Keywords: ppar; group; dena induced; induced lung ... See more keywords
Potential of curcumin and resveratrol as biochemical and biophysical modulators during lung cancer in rats
Sign Up to like & getrecommendations! Published in 2019 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2018.1523921
Abstract: Abstract The present study explored chemopreventive aspects of curcumin and resveratrol in the experimental model of lung carcinogenesis in rats. The main aim was to establish efficacy of combined phytochemicals treatment over individual treatments in… read more here.
Keywords: resveratrol; curcumin resveratrol; treated rats; cancer ... See more keywords
Suppressing the activation of protein kinase A as a DNA damage-independent mechanistic lead for dihydromethysticin (DHM) prophylaxis of NNK-induced lung carcinogenesis.
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DOI: 10.1093/carcin/bgac031
Abstract: Our earlier work demonstrated varying potency of dihydromethysticin (DHM) as the active kava phytochemical for prophylaxis of tobacco carcinogen NNK-induced mouse lung carcinogenesis. Efficacy was dependent on timing of DHM gavage ahead of NNK insult.… read more here.
Keywords: damage; lung carcinogenesis; nnk induced; damage independent ... See more keywords
Muc1 knockout potentiates murine lung carcinogenesis involving an epiregulin-mediated EGFR activation feedback loop
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DOI: 10.1093/carcin/bgx039
Abstract: Mucin 1 (MUC1) is a tumor antigen that is aberrantly overexpressed in various cancers, including lung cancer. Our previous in vitro studies showed that MUC1 facilitates carcinogen-induced EGFR activation and transformation in human lung bronchial… read more here.
Keywords: muc1; lung cancer; lung carcinogenesis; lung ... See more keywords
Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-019-1838-y
Abstract: BackgroundHypercoagulation and neutrophilia are described in several cancers, however, whether they are involved in lung carcinogenesis is currently unknown. Emodin is the main bioactive component from Rheum palmatum and has many medicinal values, such as… read more here.
Keywords: hypercoagulation; emodin; lung; hypercoagulation lung ... See more keywords