Lung deposition versus inhalable sampling to estimate body burden of welding fume exposure: A pilot sampler study in stainless steel welders
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Aerosol Science"
DOI: 10.1016/j.jaerosci.2020.105721
Abstract: Abstract This pilot study evaluated the ability of a lung deposition sampler (LDS) to estimate body burden by comparing lung-deposited and inhalable nickel and chromium exposures to biomarkers of internal dose. A cohort of stainless… read more here.
Keywords: body burden; lung deposition; exposure; lung ... See more keywords
Ambient Size Distributions and Lung Deposition of Aerosol Dithiothreitol-Measured Oxidative Potential: Contrast between Soluble and Insoluble Particles.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental science & technology"
DOI: 10.1021/acs.est.7b01536
Abstract: Ambient particulate matter may upset redox homeostasis, leading to oxidative stress and adverse health effects. Size distributions of water-insoluble and water-soluble OPDTT (dithiothreitol assay, measure of oxidative potential per air volume) are reported for a… read more here.
Keywords: size distributions; water; water insoluble; lung deposition ... See more keywords
Maximizing Deep Lung Deposition in Healthy and Fibrotic Subjects During Jet Nebulization
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Aerosol Medicine and Pulmonary Drug Delivery"
DOI: 10.1089/jamp.2019.1552
Abstract: Background: In volunteers with idiopathic pulmonary fibrosis (IPF), inhaled Interferon-γ (IFN-γ) is safe and may improve pulmonary function. However, coughing, associated with upper airway deposition, is often reported. To address this problem, a small-particle, breath-enhanced… read more here.
Keywords: jet; upper airway; deposition; airway deposition ... See more keywords
Do dry powder inhalers (DPIs) have a ‘Goldilocks Zone’ of inhalation? In vitro lung deposition of Budesonide/Formoterol (BUD/FORM) DPI with different inhalation profiles
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/1393003.congress-2017.pa526
Abstract: Introduction: Patients need to inhale forcefully when using a DPI to generate fine particle dose (FPD) for inhalation. However, fast inhalations may lead to increased impaction of drug in the mouth and throat. Aims &… read more here.
Keywords: deposition; bud form; rate; inhalation ... See more keywords
Lung deposition of extrafine inhaled corticosteroid (ICS)-containing fixed combinations drug in COPD patients using Functional Respiratory Imaging (FRI).
Sign Up to like & getrecommendations! Published in 2018 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2018.pa1015
Abstract: Introduction: FRI is a novel computational fluid dynamics (CFD)-based technique using formulation profile and patients lung CT scan to simulate aerosol deposition. Aims and objectives: To evaluate lung deposition of pressurized metered dose inhaler (pMDI)… read more here.
Keywords: pmdi; deposition; drug; extrafine ... See more keywords
Effects of Formulation Variables on Lung Dosimetry of Albuterol Sulfate Suspension and Beclomethasone Dipropionate Solution Metered Dose Inhalers
Sign Up to like & getrecommendations! Published in 2018 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-018-1071-7
Abstract: The performance of pressurized metered dose inhalers (MDIs) is affected by formulation and device variables that impact delivered dose, aerodynamic particle size distribution, and consequently lung deposition and therapeutic effect. Specific formulation variables of relevance… read more here.
Keywords: formulation variables; deposition; suspension; solution ... See more keywords
Administration of Bacteriophages via Nebulization during Mechanical Ventilation: In Vitro Study and Lung Deposition in Macaques
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15030602
Abstract: Bacteriophages have been identified as a potential treatment option to treat lung infection in the context of antibiotic resistance. We performed a preclinical study to predict the efficacy of delivery of bacteriophages against Pseudomonas aeruginosa… read more here.
Keywords: via nebulization; nebulization; lung; ventilation ... See more keywords