The reduction in FOXA2 activity during lung development in fetuses from diabetic rat mothers is reversed by Akt inhibition
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12517
Abstract: Hyperglycemia during pregnancy is associated with fetal lung development disorders and surfactant protein (SP) deficiency. Here, we examined the role of FOXA2 and Akt signaling in fetal lung development during diabetic pregnancy. Sprague‐Dawley rats were… read more here.
Keywords: reduction foxa2; foxa2; fetal lung; lung development ... See more keywords
Perinatal nicotine exposure alters lung development and induces HMGB1‐RAGE expression in neonatal mice
Sign Up to like & getrecommendations! Published in 2020 at "Birth Defects Research"
DOI: 10.1002/bdr2.1840
Abstract: Maternal nicotine exposure during gestation and lactation adversely affect lung development of their children. High‐mobility group box 1 (HMGB1) is the encoded non‐histone, nuclear DNA‐binding protein that regulates transcription, and is involved in organization of… read more here.
Keywords: hmgb1 rage; rage expression; nicotine exposure; exposure ... See more keywords
Explant Culture for Studying Lung Development.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7714-7_8
Abstract: Lung development is a complex process that requires the input of various signaling pathways to coordinate the specification and differentiation of multiple cell types. Ex vivo culture of the lung is a very useful technique… read more here.
Keywords: culture studying; explant culture; lung development; development ... See more keywords
Yes-associated protein is dysregulated during nitrofen-induced hypoplastic lung development due to congenital diaphragmatic hernia
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Surgery International"
DOI: 10.1007/s00383-022-05099-x
Abstract: Congenital diaphragmatic hernia (CDH) is a birth defect associated with abnormal lung development. Yes-associated protein (YAP) is a core kinase of the Hippo pathway, which controls organ size during development. The absence of YAP protein… read more here.
Keywords: development; lung; lung development; yap ... See more keywords
How high resolution 3-dimensional imaging changes our understanding of postnatal lung development
Sign Up to like & getrecommendations! Published in 2018 at "Histochemistry and Cell Biology"
DOI: 10.1007/s00418-018-1749-7
Abstract: During the last 10 + years biologically and clinically significant questions about postnatal lung development could be answered due to the application of modern cutting-edge microscopic and quantitative histological techniques. These are in particular synchrotron radiation based… read more here.
Keywords: high resolution; dimensional imaging; postnatal lung; lung development ... See more keywords
Hyperoxia exposure disrupts adrenomedullin signaling in newborn mice: Implications for lung development in premature infants.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.04.112
Abstract: Hyperoxia contributes to the development of bronchopulmonary dysplasia (BPD), a chronic lung disease of human infants that is characterized by disrupted lung angiogenesis. Adrenomedullin (AM) is a multifunctional peptide with angiogenic and vasoprotective properties. AM… read more here.
Keywords: hyperoxia exposure; neonatal mice; mice; lung development ... See more keywords
Metabolomic profiling of human pluripotent stem cell differentiation into lung progenitors
Sign Up to like & getrecommendations! Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2022.103797
Abstract: Summary Metabolism is vital to cellular function and tissue homeostasis during human lung development. In utero, embryonic pluripotent stem cells undergo endodermal differentiation toward a lung progenitor cell fate that can be mimicked in vitro… read more here.
Keywords: lung; differentiation; lung development; pluripotent stem ... See more keywords
Temporal, spatial, and phenotypical changes of PDGFRα expressing fibroblasts during late lung development.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.03.020
Abstract: Many studies have investigated the source and role of epithelial progenitors during lung development; such information is limited for fibroblast populations and their complex role in the developing lung. In this study, we characterized the… read more here.
Keywords: muscle; pdgfr fibroblasts; expression; pdgfr expressing ... See more keywords
A three-dimensional model of human lung development and disease from pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Nature cell biology"
DOI: 10.1038/ncb3510
Abstract: Recapitulation of lung development from human pluripotent stem cells (hPSCs) in three dimensions (3D) would allow deeper insight into human development, as well as the development of innovative strategies for disease modelling, drug discovery and… read more here.
Keywords: disease; model; pluripotent stem; lung development ... See more keywords
Mesenchyme-specific deletion of Tgf-β1 in the embryonic lung disrupts branching morphogenesis and induces lung hypoplasia
Sign Up to like & getrecommendations! Published in 2019 at "Laboratory Investigation"
DOI: 10.1038/s41374-019-0256-3
Abstract: Proper lung development depends on the precise temporal and spatial expression of several morphogenic factors, including Fgf10, Fgf9, Shh, Bmp4, and Tgf-β. Over- or under-expression of these molecules often leads to aberrant embryonic or postnatal… read more here.
Keywords: tgf; lung development; lung hypoplasia; lung ... See more keywords
Epigenetic reactivation of transcriptional programs orchestrating fetal lung development in human pulmonary hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abe5407
Abstract: Phenotypic alterations in resident vascular cells contribute to the vascular remodeling process in diseases such as pulmonary (arterial) hypertension [P(A)H]. How the molecular interplay between transcriptional coactivators, transcription factors (TFs), and chromatin state alterations facilitate… read more here.
Keywords: epigenetic reactivation; lung development; reactivation; hypertension ... See more keywords