Lung‐Targeted Rnai Therapeutics: Lung‐Endothelium‐Targeted Nanoparticles Based on a pH‐Sensitive Lipid and the GALA Peptide Enable Robust Gene Silencing and the Regression of Metastatic Lung Cancer (Adv. Funct. Mater. 18/2019)
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DOI: 10.1002/adfm.201970121
Abstract: advanced materials that can achieve specific cellular targeting together with efficient intracellular trafficking for reaching target sites in the cytosol. In article number 1807677, Ikramy A. Khalil, Hideyoshi Harashima, and co-workers use nanoparticles modified with… read more here.
Keywords: lung; metastatic lung; lung endothelium; robust gene ... See more keywords
Genetic Factors as the Basis of Sex Differences in Damage to Lung Endothelium and Regulation of Angiogenesis Cells in Modeling Pulmonary Emphysema in C57BL/6 Mice with Dyslipidemia and Hyperglycemia
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DOI: 10.1007/s10517-021-05061-2
Abstract: We studied the formation of injuries in lung endothelium and the response of angiogenesis cells during modeling of pulmonary emphysema in male and female C57BL/6 mice with metabolic disorders. Hemodynamic disturbances and reduction in the… read more here.
Keywords: cells modeling; modeling pulmonary; mice; lung endothelium ... See more keywords
Optimization of a Degradable Polymer-Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells.
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DOI: 10.1021/acs.nanolett.8b02917
Abstract: mRNA therapeutics hold great potential for treating a variety of diseases through protein-replacement, immunomodulation, and gene editing. However, much like siRNA therapy the majority of progress in mRNA delivery has been confined to the liver.… read more here.
Keywords: delivery; mrna; polymer lipid; lung endothelium ... See more keywords
Injured lung endothelium: mechanisms of self-repair and agonist-assisted recovery (2017 Grover Conference Series)
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DOI: 10.1177/2045893217752660
Abstract: The lung endothelium is vulnerable to both exogenous and endogenous insults, so a properly coordinated efficient repair system is essential for the timely recovery of the lung after injury. The agents that cause endothelial injury… read more here.
Keywords: recovery; endothelium; injured lung; agonist assisted ... See more keywords