Up-regulation of THY1 attenuates interstitial pulmonary fibrosis and promotes lung fibroblast apoptosis during acute interstitial pneumonia by blockade of the WNT signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1578144
Abstract: ABSTRACT Acute interstitial pneumonia (AIP) is an idiopathic pulmonary disease featuring rapid progressive dyspnea and respiratory failure. These symptoms typically develop within several days or weeks in patients without any pre-existing lung disease or external… read more here.
Keywords: thy1; apoptosis; lung fibroblast; pulmonary fibrosis ... See more keywords
Sox9 protects against human lung fibroblast cell apoptosis induced by LPS through activation of the AKT/GSK3β pathway
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry (Moscow)"
DOI: 10.1134/s000629791705008x
Abstract: Sex-determining region Y-box 9 (Sox9) is an important transcription factor that has been identified as a key regulator of several types of diseases. In this study, we explored the correlation of Sox9 with cell proliferation,… read more here.
Keywords: fibroblast cell; apoptosis; lung fibroblast; pathway ... See more keywords
Iron controls lung fibroblast activation and invasion via SH3RF1/HIPK2 pathway
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5728277
Abstract: Iron is a metal element indispensable for nearly all living organisms, as it participates in a variety of biological processes. The homeostasis of iron is essential to human health. Iron-responsive element-binding proteins (IRP1 and IRP2)… read more here.
Keywords: iron; fibroblast activation; physiology; sh3rf1 ... See more keywords
MYH9 Inhibition Suppresses TGF-β1-Stimulated Lung Fibroblast-to-Myofibroblast Differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.573524
Abstract: Previous cDNA microarray results showed that MYH9 gene expression levels are increased in TGF-β1-stimulated lung fibroblast. Recently, our proteomic results revealed that the expression levels of MYH9 protein are notably upregulated in lung tissues of… read more here.
Keywords: lung; lung fibroblast; differentiation; tgf stimulated ... See more keywords
P-Rex1 Cooperates With TGFβR2 to Drive Lung Fibroblast Migration in Pulmonary Fibrosis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.678733
Abstract: Pulmonary fibrosis is a kind of interstitial lung disease with progressive pulmonary scar formation, leading to irreversible loss of lung functions. The TGF-β1/Smad signaling pathway plays a key role in fibrogenic processes. It is associated… read more here.
Keywords: fibrosis; rex1; migration; lung fibroblast ... See more keywords
Molecular Regulation of Heme Oxygenase-1 Expression by E2F Transcription Factor 2 in Lung Fibroblast Cells: Relevance to Idiopathic Pulmonary Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12101531
Abstract: Idiopathic pulmonary fibrosis (IPF) is a fatal chronic lung disease. Heme oxygenase-1 (HMOX1/HO-1) is an enzyme that catalyzes the degradation of heme. The role of HO-1 in the pathogenesis of IPF has been studied; however,… read more here.
Keywords: heme; expression; lung; lung fibroblast ... See more keywords
BML-111 suppresses TGF-β1-induced lung fibroblast activation in vitro and decreases experimental pulmonary fibrosis in vivo
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2018.3914
Abstract: Pulmonary fibrosis is an aggressive end-stage disease. Transforming growth factor-β1 (TGF-β1) mediates lung fibroblast activation and is essential for the progress of pulmonary fibrosis. BML-111, a lipoxinA4 (LXA4) receptor (ALX) agonist, has been reported to… read more here.
Keywords: lung fibroblast; tgf induced; pulmonary fibrosis; activation ... See more keywords