Tenascin-C activation of lung fibroblasts in a 3D synthetic lung extracellular matrix mimic.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202301493
Abstract: The lung extracellular matrix (ECM) maintains the structural integrity of the tissue and regulates the phenotype and functions of resident fibroblasts. Lung-metastatic breast cancer alters these cell-ECM interactions, promoting fibroblast activation. There is a need… read more here.
Keywords: extracellular matrix; lung fibroblasts; lung extracellular; lung ... See more keywords
An inflammatory stimulus sensitizes TRPA1 channel to increase cytokine release in human lung fibroblasts.
Sign Up to like & getrecommendations! Published in 2020 at "Cytokine"
DOI: 10.1016/j.cyto.2020.155027
Abstract: External stimuli such as cigarette smoke and house dust mite are often involved in the development and exacerbation of asthma. These risk factors could activate or sensitize transient receptor potential channel ankyrin 1 (TRPA1), which… read more here.
Keywords: lung fibroblasts; cytokine release; human lung; trpa1 channel ... See more keywords
LncRNA-PVT1 activates lung fibroblasts via miR-497-5p and is facilitated by FOXM1.
Sign Up to like & getrecommendations! Published in 2021 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2021.112030
Abstract: It is little known about the lncRNA-PVT1 effect on occupational pulmonary fibrosis, although researches show it plays an essential role in cancer. Studies reveal that lung fibroblast activation is one of the key events in… read more here.
Keywords: lncrna pvt1; lung fibroblasts; pvt1; mir 497 ... See more keywords
Dothiorelone derivatives from an endophyte Diaporthe pseudomangiferaea inhibit the activation of human lung fibroblasts MRC-5 cells.
Sign Up to like & getrecommendations! Published in 2018 at "Fitoterapia"
DOI: 10.1016/j.fitote.2018.04.009
Abstract: Nine new compounds (1-6 and 16-18) and nine known compounds (7-15) were isolated from Diaporthe pseudomangiferaea, an endophytic fungus obtained from the leaves of the toxic Chinese folk medicine Tylophora ouata. Their structures were elucidated… read more here.
Keywords: lung fibroblasts; activation human; fibroblasts mrc; mrc cells ... See more keywords
Proteomic profile of TGF‐&bgr;1 treated lung fibroblasts identifies novel markers of activated fibroblasts in the silica exposed rat lung
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2019.01.010
Abstract: ABSTRACT We performed liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) on control and TGF‐&bgr;1‐exposed rat lung fibroblasts to identify proteins differentially expressed between cell populations. A total of 196 proteins were found to be differentially expressed in… read more here.
Keywords: tgf bgr; rat lung; lung fibroblasts; lung ... See more keywords
Lung fibroblasts promote metastatic colonization through upregulation of stearoyl-CoA desaturase 1 in tumor cells
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-017-0062-6
Abstract: As a rate-limiting step in metastasis, metastatic colonization requires survival signals from supportive stroma. However, the mechanisms driving this process are incompletely understood. Here, we showed that the proliferation of B16F10 cells was promoted when… read more here.
Keywords: metastatic colonization; tumor cells; lung fibroblasts; tumor ... See more keywords
Transcriptional regulation of the IL-13Rα2 gene in human lung fibroblasts
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-57972-1
Abstract: Interleukin (IL)−13 is a type 2 cytokine with important roles in allergic diseases, asthma, and tissue fibrosis. Its receptor (R) α1 is primarily responsible for the biological actions of this cytokine, while Rα2 possesses a… read more here.
Keywords: lung fibroblasts; lung; human lung; induction ... See more keywords
LncRNA PFAR contributes to fibrogenesis in lung fibroblasts through competitively binding to miR-15a
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20190280
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, debilitating disease with unknown etiopathogenesis. Previous reports have reported that long non-coding RNAs (lncRNAs) were involved in various pathophysiological processes. However, the role of lncRNAs in IPF… read more here.
Keywords: lncrna pfar; lung fibroblasts; fibrosis; mir 15a ... See more keywords
Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac630
Abstract: Abstract The lung is a complex organ with various cell types having distinct roles. Antisense oligonucleotides (ASOs) have been studied in the lung, but it has been challenging to determine their effectiveness in each cell… read more here.
Keywords: cell; cell types; lung fibroblasts; gene silencing ... See more keywords
Clusterin as a serum biomarker candidate contributes to the lung fibroblasts activation in chronic obstructive pulmonary disease
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000002065
Abstract: Abstract Background: Fibrosis in the peripheral airways contributes to airflow limitation in patients with chronic obstructive pulmonary disease (COPD). However, the key proteins involved in its development are still poorly understood. Thus, we aimed to… read more here.
Keywords: lung; biomarker candidate; lung fibroblasts; disease ... See more keywords
Naftopidil reduced the proliferation of lung fibroblasts and bleomycin‐induced lung fibrosis in mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14255
Abstract: Naftopidil, an α‐1 adrenoceptor antagonist with few adverse effects, is prescribed for prostate hyperplasia. Naftopidil inhibits prostate fibroblast proliferation; however, its effects on lung fibroblasts and fibrosis remain largely unknown. Two normal and one idiopathic… read more here.
Keywords: bleomycin induced; fibrosis; lung fibroblasts; induced lung ... See more keywords