Lung fibrosis in autoimmune diseases and hypersensitivity: how to separate these from idiopathic pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology International"
DOI: 10.1007/s00296-021-05002-2
Abstract: Lung involvement in autoimmune diseases (AID) is uncommon, but may precede other organ manifestations. A diagnostic problem is chronicity presenting with lung fibrosis. A new category of interstitial pneumonia with autoimmune features for patients with… read more here.
Keywords: autoimmune; fibrosis; etiology; aid ... See more keywords
Experimental pulmonary fibrosis was suppressed by microRNA-506 through NF-kappa-mediated apoptosis and inflammation
Sign Up to like & getrecommendations! Published in 2019 at "Cell and Tissue Research"
DOI: 10.1007/s00441-019-03054-2
Abstract: Fibrosis in the lungs usually occurs in the initial phase of acute respiratory distress syndrome (ARDS), which exacerbates poor prognosis among patients. MicroRNAs (miRs) have the ability to modulate the expression profiles of many genes,… read more here.
Keywords: lung fibrosis; mir 506; fibrosis; apoptosis ... See more keywords
Anti-fibrotic nintedanib—a new opportunity for systemic sclerosis patients?
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Rheumatology"
DOI: 10.1007/s10067-017-3867-3
Abstract: Systemic sclerosis is a connective tissue disease characterized by progressive skin thickening and a wide spectrum of internal organ involvement. Pathogenesis includes vasculopathy, inflammation, and fibrosis. Although immunosuppressants such as cyclophosphamide and mycophenolate mofetil have… read more here.
Keywords: sclerosis; systemic sclerosis; anti fibrotic; lung fibrosis ... See more keywords
Activation and overexpression of Sirt1 attenuates lung fibrosis via P300.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.155
Abstract: Persistent fibroblast activation is a predominant feature of idiopathic pulmonary fibrosis (IPF), but the transcriptional and epigenetic mechanisms controlling this process are not well understood. Silent information regulator type-1 (Sirt1) is a member of class… read more here.
Keywords: sirt1; lung fibrosis; activation overexpression; fibrosis ... See more keywords
Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2019.11.027
Abstract: Fibrosis can develop in most organs and causes organ failure. The most common type of lung fibrosis is known as idiopathic pulmonary fibrosis, in which fibrosis starts at the lung periphery and then progresses toward… read more here.
Keywords: elevated mechanical; fibrosis; lung fibrosis; mechanical tension ... See more keywords
Suppressive effects on lung fibrosis and the polarization and populations of macrophages by liposomal clodronate combined with pirfenidone
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.338
Abstract: Purpose Effective treatment of idiopathic pulmonary fibrosis (IPF) is still difficult. Macrophages (Mφ) are closely related to IPF. M1 phenotype Mφ exhibit proinflammatory properties, M2 phenotype Mφ promote fibrogenesis. We found that pirfenidone (PFD), a… read more here.
Keywords: liposomal clodronate; fibrosis; polarization populations; lung fibrosis ... See more keywords
UUO induces lung fibrosis with macrophage-myofibroblast transition in rats.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107396
Abstract: Progression of chronic kidney disease (CKD) to uremia is often accompanied by varying degrees of lung damage and this is also an important cause of death. Although there are many studies on the mechanism of… read more here.
Keywords: myofibroblast transition; lung fibrosis; macrophage myofibroblast; fibrosis ... See more keywords
Copper as the most likely pathogenic divergence factor between lung fibrosis and emphysema.
Sign Up to like & getrecommendations! Published in 2018 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2018.08.003
Abstract: Although fibrosis and emphysema are in many ways on opposite ends of the pulmonary parenchymal disease spectrum, they seem to share common pathomechanistic steps. This is illustrated by the coexistence of both entities in lungs… read more here.
Keywords: fibrosis; fibrosis emphysema; emphysema; factor ... See more keywords
GANE can Improve Lung Fibrosis by Reducing Inflammation via Promoting p38MAPK/TGF-β1/NF-κB Signaling Pathway Downregulation
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c06591
Abstract: There is a trend to use nanoparticles as distinct treatments for cancer treatment because they have overcome many of the limitations of traditional drug delivery systems. Gallic acid (GA) is an effective polyphenol in the… read more here.
Keywords: lung; lung fibrosis; gane; p38mapk tgf ... See more keywords
5-aza-2′-deoxycytidine, a DNA methylation inhibitor, attenuates hyperoxia-induced lung fibrosis via re-expression of P16 in neonatal rats
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Research"
DOI: 10.1038/pr.2017.291
Abstract: BackgroundP16 methylation plays an important role in the pathogenesis of hyperoxia-induced lung fibrosis. 5-aza-2′-deoxycytidine (5-aza-CdR) is a major methyltransferase-specific inhibitor. In this study, the effects of 5-aza-CdR on a hyperoxia-induced lung fibrosis in neonatal rats… read more here.
Keywords: methylation; p16; expression; lung fibrosis ... See more keywords
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17358-3
Abstract: The cell type specific sequences of transcriptional programs during lung regeneration have remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, we resolved transcriptional dynamics for 28 cell types. Trajectory modeling… read more here.
Keywords: regeneration; stem cell; krt8 transitional; stem ... See more keywords