Lung infection caused by Pseudomonas aeruginosa in a CD26/DPP4 deficient F344 rat model
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation Research"
DOI: 10.1007/s00011-019-01236-w
Abstract: BackgroundPseudomonas aeruginosa (PA) is the most important opportunistic pathogen in causing nosocomial infections and, furthermore, poses a permanent threat for severe chronic infections in patients with cystic fibrosis or COPD. The transmembrane protein CD26 with… read more here.
Keywords: dpp4; lung infection; cd26; cd26 dpp4 ... See more keywords
Antimicrobial polymers as therapeutics for treatment of multidrug-resistant Klebsiella pneumoniae lung infection.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.07.038
Abstract: Klebsiella pneumoniae (K. pneumoniae) is one of the most common pathogens in hospital-acquired infections. It is often resistant to multiple antibiotics (including carbapenems), and can cause severe pneumonia. In search of effective antimicrobials, we recently… read more here.
Keywords: treatment; pneumoniae; lung infection; pneumoniae lung ... See more keywords
Experimental traumatic brain injury does not lead to lung infection
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2020.577239
Abstract: Traumatic brain injury (TBI) patients often experience post-traumatic infections, especially in the lung. Pulmonary infection is associated with unfavorable outcomes and increased mortality rates in TBI patients; however, our understanding of the underlying mechanisms is… read more here.
Keywords: brain injury; traumatic brain; infection; lung infection ... See more keywords
Size and Charge Adaptive Clustered Nanoparticles Targeting Biofilm Microenvironment for Chronic Lung Infection Management.
Sign Up to like & getrecommendations! Published in 2020 at "ACS nano"
DOI: 10.1021/acsnano.0c00269
Abstract: Chronic lung infection caused by bacterial biofilms is an extremely serious clinical problem, which can lead to the failure of antibiotic therapy. Although nanoparticles have shown great potential in the treatment of biofilms, the efficient… read more here.
Keywords: azm nps; chronic lung; lung infection;
Neutrophil pyroptosis mediates pathology of P. aeruginosa lung infection in the absence of the NADPH oxidase NOX2
Sign Up to like & getrecommendations! Published in 2017 at "Mucosal Immunology"
DOI: 10.1038/mi.2016.73
Abstract: Nod-like receptor family, CARD domain-containing 4 (NLRC4) inflammasome activation is required for efficient clearance of intracellular pathogens through caspsase-1-dependent pyroptosis in macrophages. Although neutrophils have a critical role in protection from Pseudomonas aeruginosa infection, the… read more here.
Keywords: pyroptosis; neutrophil pyroptosis; lung infection; pathology ... See more keywords
Studying human lung infection in mice
Sign Up to like & getrecommendations! Published in 2019 at "Nature Methods"
DOI: 10.1038/s41592-019-0672-8
Abstract: Mice implanted with human lung tissue model pathogen infection and immune responses. read more here.
Keywords: infection mice; human lung; lung infection; studying human ... See more keywords
C1q Confers Protection Against Cryptococcal Lung Infection by Alleviating Inflammation and Reducing Cryptococcal Virulence
Sign Up to like & getrecommendations! Published in 2023 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofad151
Abstract: Abstract Background To define the role of C1qa in host defense against Cryptococcus neoformans lung infection, we investigated its susceptibility to cryptococcal lung infection in mice deficient in complement factor C1qa (C1qa−/−). Methods We established… read more here.
Keywords: c1qa; deficient; lung infection; mice ... See more keywords
Methicillin-resistant Staphylococcus aureus lung infection in coronavirus disease 2019: how common?
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Infectious Diseases"
DOI: 10.1097/qco.0000000000000813
Abstract: Purpose of review Some patients with coronavirus disease 2019 (COVID-19) may develop pulmonary bacterial coinfection or superinfection, that could unfavorably impact their prognosis. Recent findings The exact burden of methicillin-resistant Staphylococcus aureus (MRSA) lung infection… read more here.
Keywords: coronavirus disease; methicillin resistant; infection; lung infection ... See more keywords
Boundary Guided Semantic Learning for Real-Time COVID-19 Lung Infection Segmentation System
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Consumer Electronics"
DOI: 10.1109/tce.2022.3205376
Abstract: The coronavirus disease 2019 (COVID-19) continues to have a negative impact on healthcare systems around the world, though the vaccines have been developed and national vaccination coverage rate is steadily increasing. At the current stage,… read more here.
Keywords: boundary guided; guided semantic; infection; lung infection ... See more keywords
In Vivo Pharmacokinetic/Pharmacodynamic Targets of Levonadifloxacin against Staphylococcus aureus in a Neutropenic Murine Lung Infection Model
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00909-19
Abstract: Levonadifloxacin is a novel benzoquinolizine subclass of fluoroquinolone, active against quinolone-resistant Staphylococcus aureus. A phase 3 trial for levonadifloxacin and its oral prodrug was recently completed. The present study identified area under the concentration-time curve… read more here.
Keywords: neutropenic murine; murine lung; staphylococcus aureus; lung infection ... See more keywords
Pharmacodynamics of Temocillin in Neutropenic Murine Infection Models
Sign Up to like & getrecommendations! Published in 2023 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01433-22
Abstract: Temocillin is used for the treatment of various infections caused by Enterobacterales. The pharmacokinetic (PK)/pharmacodynamic (PD) index that is best correlated with the activity of beta-lactams is the percentage of time that the unbound concentration… read more here.
Keywords: infection models; pneumoniae; infection; lung infection ... See more keywords