Efficacy of Losartan in Hospitalized Patients With COVID-19–Induced Lung Injury
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DOI: 10.1001/jamanetworkopen.2022.2735
Abstract: Key Points Question What is the effect of losartan on lung injury in hospitalized patients with COVID-19? Findings In this randomized clinical trial in 205 patients with evidence of COVID-19–induced acute lung injury, angiotensin receptor… read more here.
Keywords: hospitalized patients; lung injury; covid induced; injury ... See more keywords
An mTOR siRNA‐Loaded Spermidine/DNA Tetrahedron Nanoplatform with a Synergistic Anti‐Inflammatory Effect on Acute Lung Injury (Adv. Healthcare Mater. 11/2022)
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DOI: 10.1002/adhm.202200008
Abstract: Acute lung injury (ALI) is characterized by severe inflammation and damage to the lung air-blood barrier, resulting in respiratory function damage and life-threatening outcomes. Macrophage polarization plays an essential role in the occurrence, development, and… read more here.
Keywords: acute lung; dna; lung injury; anti inflammatory ... See more keywords
Nano-Enabled Reposition of Proton Pump Inhibitors for TLR Inhibition: Toward A New Targeted Nanotherapy for Acute Lung Injury.
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DOI: 10.1002/advs.202104051
Abstract: Toll-like receptor (TLR) activation in macrophages plays a critical role in the pathogenesis of acute lung injury (ALI). While TLR inhibition is a promising strategy to control the overwhelming inflammation in ALI, there still lacks… read more here.
Keywords: proton pump; nano enabled; tlr; lung injury ... See more keywords
Discovery of new cinnamic derivatives as anti‐inflammatory agents for treating acute lung injury in mice
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DOI: 10.1002/ardp.202200191
Abstract: The blockade of the overexpression of pro‐inflammatory cytokines by anti‐inflammatory natural products has been proven therapeutically beneficial in the treatment of acute lung injury (ALI). Given the fact that cinnamic acid has been proven to… read more here.
Keywords: cinnamic derivatives; anti inflammatory; acute lung; lung injury ... See more keywords
Impact of pre‐existing interstitial lung abnormal shadow on lung injury development and severity in patients of non‐small cell lung cancer treated with osimertinib
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DOI: 10.1002/cam4.4750
Abstract: First‐generation epidermal growth factor receptor‐tyrosine kinase inhibitor (EGFR‐TKI) sometimes causes lung injury, thereby affecting survival. Although pre‐existing interstitial lung abnormal shadow (pre‐ILS) increases the risk of lung injury by EGFR‐TKIs, its impact on osimertinib, a… read more here.
Keywords: lung; existing interstitial; pre existing; lung injury ... See more keywords
Long non‐coding RNA MALAT1 sponges miR‐149 to promote inflammatory responses of LPS‐induced acute lung injury by targeting MyD88
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11235
Abstract: Acute lung injury (ALI) caused by sepsis occurs early and the condition is severe, and is also an important reason for accelerating the death of patients. Increasing evidence has identified long non‐coding RNA (lncRNA) metastasis… read more here.
Keywords: lung injury; lps induced; mir 149; malat1 ... See more keywords
USP9X promotes lipopolysaccharide‐stimulated acute lung injury by deubiquitination of NLRP3
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DOI: 10.1002/cbin.11932
Abstract: Alveolar epithelial cells (AECs) function as a vital defense barrier avoiding the invasion of exogenous agents and preserving the functional and structural integrity of lung tissues, while damage/breakdown of this airway epithelial barrier is frequently… read more here.
Keywords: acute lung; lung injury; pyroptosis; lung ... See more keywords
L6H9 attenuates LPS‐induced acute lung injury in rats through targeting MD2
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DOI: 10.1002/ddr.21607
Abstract: Acute lung injury (ALI) is a clinical syndrome characterized by respiratory failure and acute inflammatory response. Myeloid differentiation protein 2 (MD2) has been reported to play a pivotal role in the recognition of LPS and… read more here.
Keywords: md2; lps induced; acute lung; attenuates lps ... See more keywords
Exposure to aerosolized staphylococcal enterotoxin B potentiated by lipopolysaccharide modifies lung transcriptomes and results in lung injury in the mouse model
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DOI: 10.1002/jat.4289
Abstract: Lipopolysaccharide (LPS) is one of the main constituents of the cell wall in Gram‐negative bacteria. Staphylococcal enterotoxin B (SEB) is produced by the Gram‐positive opportunistic pathogen, Staphylococcus aureus. Emerging evidence suggests that intraperitoneal injection of… read more here.
Keywords: lung injury; seb; exposure aerosolized; aerosolized seb ... See more keywords
Alkannin attenuates lipopolysaccharide‐induced lung injury in mice via Rho/ROCK/NF‐κB pathway
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DOI: 10.1002/jbt.22323
Abstract: We investigated the effects and associated mechanism of alkannin (AL) on lipopolysaccharide (LPS)‐induced acute lung injury in a mouse model. Pretreatment with AL in vivo significantly reduced the lung wet/dry weight ratio and inhibited lung… read more here.
Keywords: rock; mice; lung injury; rho rock ... See more keywords
Geraniol relieves mycoplasma pneumonia infection‐induced lung injury in mice through the regulation of ERK/JNK and NF‐κB signaling pathways
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22984
Abstract: Pneumonia is a serious pediatric lung injury disease caused by Mycoplasma pneumoniae (M. pneumoniae) with increasing global prevalence every year. The WHO has reported that nearly 19% of children die due to pneumonia worldwide. read more here.
Keywords: geraniol relieves; lung injury; pneumonia infection; mycoplasma pneumonia ... See more keywords