Walking Dead Tumor Cells for Targeted Drug Delivery Against Lung Metastasis of Triple‐Negative Breast Cancer
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DOI: 10.1002/adma.202205462
Abstract: Lung metastasis is challenging in patients with triple‐negative breast cancer (TNBC). Surgery is always not available due to the dissemination of metastatic foci and most drugs are powerless because of poor retention at metastatic sites.… read more here.
Keywords: lung; tnbc cells; lung metastasis; walking dead ... See more keywords
XIAP overexpression promotes bladder cancer invasion in vitro and lung metastasis in vivo via enhancing nucleolin‐mediated Rho‐GDIβ mRNA stability
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DOI: 10.1002/ijc.31223
Abstract: Our recent studies demonstrate that X‐linked inhibitor of apoptosis protein (XIAP) is essential for regulating colorectal cancer invasion. Here, we discovered that RhoGDIβ was a key XIAP downstream effector mediating bladder cancer (BC) invasion in… read more here.
Keywords: cancer; xiap; cancer invasion; lung metastasis ... See more keywords
Integration of whole‐genome sequencing and functional screening identifies a prognostic signature for lung metastasis in triple‐negative breast cancer
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DOI: 10.1002/ijc.32329
Abstract: Lung metastasis is one of the leading causes of death for triple‐negative breast cancer (TNBC). We sought to characterize the genetic alterations underlying TNBC lung metastases by integrating whole‐genome sequencing and functional screening. Furthermore, we… read more here.
Keywords: whole genome; metastasis; tnbc; signature ... See more keywords
Patients with colorectal cancer and brain metastasis: The relevance of extracranial metastatic patterns predicting time intervals to first occurrence of intracranial metastasis and survival
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DOI: 10.1002/ijc.33364
Abstract: The aim of the study was to investigate the predictive impact of extracranial metastatic patterns on course of disease and survival in patients with colorectal cancer (CRC) and brain metastasis (BM). A total of 228… read more here.
Keywords: extracranial metastatic; metastatic patterns; metastasis; liver metastasis ... See more keywords
Lung fibrosis is a novel therapeutic target to suppress lung metastasis of osteosarcoma
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DOI: 10.1002/ijc.34008
Abstract: The prognosis of patients with metastatic and recurrent osteosarcoma has not improved over the last 30 years because no effective treatment strategy has been established for lung metastases. Although molecular‐targeted drugs that modify the extracellular environment,… read more here.
Keywords: osteosarcoma; lung; lung metastasis; antifibrotic agents ... See more keywords
Outcomes of lung metastasis from pancreatic cancer: A nationwide multicenter analysis.
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DOI: 10.1002/jhbp.1127
Abstract: BACKGROUND Although distant metastasis from pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, some single center studies reported that lung metastasis has a favorable prognosis. The aim of this study is to evaluate the prognostic… read more here.
Keywords: analysis; lung metastasis; pancreatic cancer; outcomes lung ... See more keywords
A contrast-enhanced MRI-based nomogram to identify lung metastasis in soft-tissue sarcoma: A multi-center study.
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DOI: 10.1002/mp.16136
Abstract: BACKGROUND Lung metastasis (LM) status is critical for making treatment decisions in soft-tissue sarcoma (STS) patients, yet magnetic resonance imaging (MRI)-based prediction of LM in STSs has not been thoroughly investigated. PURPOSE This study aimed… read more here.
Keywords: radiomics signature; soft tissue; tissue sarcoma; signature margin ... See more keywords
Osteosarcoma-Derived Exosomes as Potential PET Imaging Nanocarriers for Lung Metastasis.
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DOI: 10.1002/smll.202203999
Abstract: Lung metastases represent the most adverse clinical factor and rank as the leading cause of osteosarcoma-related death. Nearly 80% of patients present lung micrometastasis at diagnosis not detected with current clinical tools. Herein, an exosome… read more here.
Keywords: osteosarcoma; derived exosomes; osteosarcoma derived; pet ... See more keywords
Pulmonary administration of curcumin inhibits B16F10 melanoma lung metastasis and invasion in mice
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DOI: 10.1007/s00280-018-3616-6
Abstract: PurposeCurcumin is expected to have beneficial effects including an anti-cancer effect. However, its lower bioavailability is a critical concern and limits the utility of curcumin in clinical practice. In this study, we investigated whether transpulmonary… read more here.
Keywords: melanoma; administration; pulmonary administration; lung metastasis ... See more keywords
Neutrophil-to-lymphocyte ratio as a prognostic marker for head and neck cancer with lung metastasis
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DOI: 10.1007/s00405-022-07394-8
Abstract: With great interest, I read a recent retrospective study quantifying the prognostic impact of neutrophil-to-lymphocyte ratio (NLR) on head and neck cancer (HNSCC) with lung metastasis [1]. In this study, Yanni A and colleagues concluded… read more here.
Keywords: lung metastasis; metastasis; neutrophil lymphocyte; head neck ... See more keywords
B7 homolog 3 induces lung metastasis of breast cancer through Raf/MEK/ERK axis
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DOI: 10.1007/s10549-022-06520-8
Abstract: The essential action of B7 homolog 3 (B7-H3) in different diseases and cancers has been documented. We here focused on its role in breast cancer through the Raf/MEK/ERK axis regarding lung metastasis. Expression pattern of… read more here.
Keywords: cancer; breast cancer; lung metastasis; mek erk ... See more keywords