Tetrandrine Alleviates Pulmonary Fibrosis by Modulating Lung Microbiota‐Derived Metabolism and Ameliorating Alveolar Epithelial Cell Senescence
Sign Up to like & getrecommendations! Published in 2024 at "Phytotherapy Research"
DOI: 10.1002/ptr.8374
Abstract: Tetrandrine (TET) is a minimally toxic drug extracted from the root of Stephania tetrandra. We previously demonstrated that TET could ameliorate pulmonary fibrosis (PF) by modulating autophagy. However, the mechanism behind TET's protective effects on… read more here.
Keywords: epithelial cell; lung microbiota; cell senescence; alveolar epithelial ... See more keywords
Past, Present, and Future Research on the Lung Microbiome in Inflammatory Airway Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Chest"
DOI: 10.1016/j.chest.2019.05.011
Abstract: COPD, asthma, and cystic fibrosis (CF) are obstructive lung diseases with distinct pathophysiologies and clinical phenotypes. In this paper, we highlight recent advances in our understanding of relationships between clinical phenotypes, host inflammatory response, and… read more here.
Keywords: host inflammatory; clinical phenotypes; lung microbiota; inflammatory response ... See more keywords
Exploring the Role of Respiratory Microbiome in Lung Cancer: a Systematic Review.
Sign Up to like & getrecommendations! Published in 2021 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2021.103404
Abstract: Giving the potential contribute in cancer initiation and progression, lung microbiota represents a promising topic in cancer research, although still unexplored. We performed a systematic literature search to identify clinical studies evaluating lung microbiota composition,… read more here.
Keywords: lung microbiota; respiratory microbiome; lung cancer; cancer ... See more keywords
Traffic generated emissions alter the lung microbiota by promoting the expansion of Proteobacteria in C57Bl/6 mice placed on a high-fat diet
Sign Up to like & getrecommendations! Published in 2021 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2021.112035
Abstract: Air pollution has been documented to contribute to severe respiratory diseases like asthma and chronic obstructive pulmonary disorder (COPD). Although these diseases demonstrate a shift in the lung microbiota towards Proteobacteria, the effects of traffic… read more here.
Keywords: fat diet; generated emissions; lung microbiota; lung ... See more keywords
Dynamic alterations in the lung microbiota in a rat model of lipopolysaccharide-induced acute lung injury
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DOI: 10.1038/s41598-022-08831-8
Abstract: The lung microbiota have been found to be substantially altered in numerous pulmonary disorders, and crosstalk between the host pathophysiology and lung microbiota plays critical roles in the regulation of disease states. The aim of… read more here.
Keywords: lung microbiota; lung injury; acute lung;
The role and mechanism of lung microbiota in coal mine dust-induced NLRP3 inflammasome upregulate and lung injury
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DOI: 10.1038/s41598-025-06411-0
Abstract: The exact molecular mechanisms of coal workers’ pneumoconiosis (CWP) are still unknown. The purpose of this study is to investigate how the lung microbiota may contribute to the development of CWP. The rats were divided… read more here.
Keywords: lung; lung microbiota; dust; coal ... See more keywords
Insights into the Unique Lung Microbiota Profile of Pulmonary Tuberculosis Patients Using Metagenomic Next-Generation Sequencing
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DOI: 10.1128/spectrum.01901-21
Abstract: Characterization of the lung microbiota could lead to a better understanding of the pathogenesis of pulmonary TB. Here, we applied the metagenomic shotgun sequencing instead of 16S rRNA sequencing method to characterize the lung microbiota… read more here.
Keywords: lung microbiota; microbiota profile; microbiota; pulmonary patients ... See more keywords
Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis
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DOI: 10.1164/rccm.201809-1650oc
Abstract: Rationale: Idiopathic pulmonary fibrosis (IPF) causes considerable global morbidity and mortality, and its mechanisms of disease progression are poorly understood. Recent observational studies have reported associations between lung dysbiosis, mortality, and altered host defense gene… read more here.
Keywords: disease progression; progression; lung microbiota; lung ... See more keywords
Response of Lung Microbiota to Changes of Pulmonary Innate Immunity under Healthy Conditions
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DOI: 10.1164/rccm.202109-2187le
Abstract: We read with much interest the research letter by Pantale on Garc ıa and colleagues regarding the response of lung microbiota to changes in pulmonary innate immunity (1). An important question that needs to be… read more here.
Keywords: pulmonary innate; lung; innate immunity; changes pulmonary ... See more keywords
Lung Microbiota of Critically Ill Patients with COVID-19 Are Associated with Nonresolving Acute Respiratory Distress Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202202-0274oc
Abstract: Rationale Bacterial lung microbiota are correlated with lung inflammation and acute respiratory distress syndrome (ARDS) and altered in severe coronavirus disease (COVID-19). However, the association between lung microbiota (including fungi) and resolution of ARDS in… read more here.
Keywords: lung; bacterial fungal; lung microbiota; respiratory ... See more keywords
Lung Microbiota Signature and Corticosteroid Responses in Pneumonia-Associated Acute Respiratory Distress Syndrome in Hematological Patients
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DOI: 10.2147/jir.s353662
Abstract: Objective In this study, we aim to classify hematological patients with the pneumonia-associated acute respiratory syndrome (ARDS) into different groups that were characterized by distinct early responsiveness to corticosteroids, describe the microbiota signatures of the… read more here.
Keywords: hematological patients; non responders; associated acute; pneumonia associated ... See more keywords