Lung organoid simulations for modelling and predicting the effect of mutations on SARS-CoV-2 infectivity
Sign Up to like & getrecommendations! Published in 2021 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2021.03.020
Abstract: The global pandemic caused by the SARS-CoV-2 virus continues to spread. Infection with SARS- CoV-2 causes COVID-19, a disease of variable severity. Mutation has already altered the SARS-CoV-2 genome from its original reported sequence and… read more here.
Keywords: mutations sars; lung organoid; infectivity; cov infectivity ... See more keywords
Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence
Sign Up to like & getrecommendations! Published in 2024 at "Respiratory Research"
DOI: 10.1186/s12931-023-02636-7
Abstract: Chronic lung diseases such as chronic obstructive pulmonary disease and cystic fibrosis are incurable. Epithelial senescence, a state of dysfunctional cell cycle arrest, contributes to the progression of such diseases. Therefore, lung epithelial cells are… read more here.
Keywords: senescence; lung; lung organoid; organoid platform ... See more keywords
Open questions in human lung organoid research
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1083017
Abstract: Organoids have become a prominent model system in pulmonary research. The ability to establish organoid cultures directly from patient tissue has expanded the repertoire of physiologically relevant preclinical model systems. In addition to their derivation… read more here.
Keywords: human lung; open questions; lung organoid; questions human ... See more keywords
3D Bioprinitng technologies for the enhancement and application of functional lung organoid models
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Bioprinting"
DOI: 10.36922/ijb.4092
Abstract: Respiratory diseases, ranging from minor infections to serious chronic diseases and malignancies, negatively affect the respiratory system and are influenced by various environmental factors such as air pollution, occupational hazards, and tobacco smoke, as well… read more here.
Keywords: lung; functional lung; lung organoid; respiratory ... See more keywords