Human lung organoids develop into adult airway-like structures directed by physico-chemical biomaterial properties.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.119757
Abstract: Tissues derived from human pluripotent stem cells (hPSCs) often represent early stages of fetal development, but mature at the molecular and structural level when transplanted into immunocompromised mice. hPSC-derived lung organoids (HLOs) transplantation has been… read more here.
Keywords: biomaterial properties; chemical biomaterial; lung organoids; like structures ... See more keywords
Generation of lung organoids from human pluripotent stem cells in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Nature Protocols"
DOI: 10.1038/s41596-018-0104-8
Abstract: The lung epithelium is derived from the endodermal germ layer, which undergoes a complex series of endoderm–mesoderm-mediated signaling events to generate the final arborized network of conducting airways (bronchi, bronchioles) and gas-exchanging units (alveoli). These… read more here.
Keywords: bud tip; lung organoids; progenitor organoids; tip progenitor ... See more keywords
Reversal of Surfactant Protein B Deficiency in Patient Specific Human Induced Pluripotent Stem Cell Derived Lung Organoids by Gene Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49696-8
Abstract: Surfactant protein B (SFTPB) deficiency is a fatal disease affecting newborn infants. Surfactant is produced by alveolar type II cells which can be differentiated in vitro from patient specific induced pluripotent stem cell (iPSC)-derived lung… read more here.
Keywords: protein; patient specific; deficiency; lung organoids ... See more keywords
Generation of Human Lung Organoid Cultures from Healthy and Tumor Tissue to Study Infectious Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00098-22
Abstract: Three-dimensional (3D) human lung organoids reflect the native cell composition of the lung as well as its physiological properties. Human 3D lung organoids offer ideal conditions, such as timely availability in large quantities and high… read more here.
Keywords: infectious diseases; human lung; lung; lung organoids ... See more keywords
Generation of Human Embryonic Stem Cell-Derived Lung Organoids for Modeling Infection and Replication Differences between Human Adenovirus Types 3 and 55 and Evaluating Potential Antiviral Drugs.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of virology"
DOI: 10.1128/jvi.00209-23
Abstract: Human adenoviruses type 3 (HAdV-3) and type 55 (HAdV-55) are frequently encountered, highly contagious respiratory pathogens with high morbidity rate. In contrast to HAdV-3, one of the most predominant types in children, HAdV-55 is a… read more here.
Keywords: cell; evaluating potential; replication; hadv ... See more keywords
State of the art on lung organoids in mammals
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary Research"
DOI: 10.1186/s13567-021-00946-6
Abstract: The number and severity of diseases affecting lung development and adult respiratory function have stimulated great interest in developing new in vitro models to study lung in different species. Recent breakthroughs in 3-dimensional (3D) organoid… read more here.
Keywords: lung organoids; art lung; organoids mammals; state art ... See more keywords
Induction of alveolar and bronchiolar phenotypes in human lung organoids
Sign Up to like & getrecommendations! Published in 2021 at "Physiological Reports"
DOI: 10.14814/phy2.14857
Abstract: Patient‐derived organoids have revolutionized biomedical research and therapies by "transferring the patient into the Petri dish". In vitro access to human lung organoids representing distal lung tissue, i.e. alveolar organoids, would facilitate research pertaining to… read more here.
Keywords: alveolar bronchiolar; bronchiolar phenotypes; lung organoids; human lung ... See more keywords
Lung Organoids in Smoking Research: Current Advances and Future Promises
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12101463
Abstract: Tobacco smoking has been established to contribute to the pathogenesis of various respiratory diseases including chronic obstructive pulmonary disease (COPD), lung cancer, and asthma. However, major hurdles in mechanistic studies on the role of smoking… read more here.
Keywords: organoids smoking; human lungs; research current; lung organoids ... See more keywords
Airway and Lung Organoids from Human-Induced Pluripotent Stem Cells Can Be Used to Assess CFTR Conductance
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076293
Abstract: Airway and lung organoids derived from human-induced pluripotent stem cells (hiPSCs) are current models for personalized drug screening, cell–cell interaction studies, and lung disease research. We analyzed the existing differentiation protocols and identified the optimal… read more here.
Keywords: airway lung; pluripotent stem; conductance; induced pluripotent ... See more keywords