A dendritic cell-based systemic vaccine induces long-lived lung-resident memory Th17 cells and ameliorates pulmonary mycosis
Sign Up to like & getrecommendations! Published in 2018 at "Mucosal Immunology"
DOI: 10.1038/s41385-018-0094-4
Abstract: Tissue-resident memory T cells (TRMs) are a novel nonvascular memory T cell subset. Although CD8+ TRMs are well-characterized, CD4+ TRMs—especially lung-resident memory Th17 cells—are still being defined. In this study, we characterized lung-resident memory Th17… read more here.
Keywords: th17 cells; resident memory; lung resident; vaccine ... See more keywords
Lung‐resident natural killer cells control pulmonary tumor growth in mice
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Science"
DOI: 10.1111/cas.13703
Abstract: Accumulating evidence indicates the importance of natural killer (NK) cells in controlling tumor growth and metastasis. NK cell subsets display diversities in their function and tissue distribution and Mac‐1hi CD27lo NK cells are the predominant… read more here.
Keywords: tumor; lung resident; pulmonary tumor; growth ... See more keywords
Unique characteristics of lung resident neutrophils are maintained by PGE2/PKA/Tgm2-mediated signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021014283
Abstract: Lung resident neutrophils need to be tightly regulated to avoid degranulation-and cytokine-associated damage to fragile alveolar structures that can lead to fatal outcomes. Here we show that lung neutrophils (LNs) express distinct surface proteins and… read more here.
Keywords: unique characteristics; resident neutrophils; characteristics lung; lung resident ... See more keywords
Age-Related Dynamics of Lung-Resident Memory CD8+ T Cells in the Age of COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.636118
Abstract: Following respiratory viral infections or local immunizations, lung resident-memory T cells (TRM) of the CD8 lineage provide protection against the same pathogen or related pathogens with cross-reactive T cell epitopes. Yet, it is now clear… read more here.
Keywords: cd8; age; pathology; resident memory ... See more keywords
A “Prime and Deploy” Strategy for Universal Influenza Vaccine Targeting Nucleoprotein Induces Lung-Resident Memory CD8 T cells
Sign Up to like & getrecommendations! Published in 2021 at "Immune Network"
DOI: 10.4110/in.2021.21.e28
Abstract: Lung-resident memory T cells (TRM) play an essential role in protecting against pulmonary virus infection. Parenteral administration of DNA vaccine is generally not sufficient to induce lung CD8 TRM cells. This study investigates whether intramuscularly… read more here.
Keywords: cd8; nucleoprotein induces; trm cells; resident memory ... See more keywords