Helper-Polymer Based Five-Element Nanoparticles (FNPs) for Lung-Specific mRNA Delivery with Long-Term Stability after Lyophilization.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c01784
Abstract: Lipid nanoparticles (LNPs) carrying therapeutic mRNAs hold great promise in treating lung-associated diseases like viral infections, tumors, and genetic disorders. However, because of their thermodynamically unstable nature, traditional LNPs carrying mRNAs need to be stored… read more here.
Keywords: specific mrna; mrna delivery; lung specific; lung ... See more keywords
A lung-specific mutational signature enables inference of viral and bacterial respiratory niche.
Sign Up to like & getrecommendations! Published in 2023 at "Microbial genomics"
DOI: 10.1099/mgen.0.001018
Abstract: Exposure to different mutagens leaves distinct mutational patterns that can allow inference of pathogen replication niches. We therefore investigated whether SARS-CoV-2 mutational spectra might show lineage-specific differences, dependent on the dominant site(s) of replication and… read more here.
Keywords: mutational signature; specific mutational; enables inference; lung specific ... See more keywords
Tuning Design Parameters of ICAM-1-Targeted 3DNA Nanocarriers to Optimize Pulmonary Targeting Depending on Drug Type
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14071496
Abstract: 3DNA holds promise as a carrier for drugs that can be intercalated into its core or linked to surface arms. Coupling 3DNA to an antibody targeting intercellular adhesion molecule 1 (ICAM-1) results in high lung-specific… read more here.
Keywords: icam targeted; lung specific; design parameters; drug ... See more keywords