Belinostat exerts antitumor cytotoxicity through the ubiquitin‐proteasome pathway in lung squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12064
Abstract: There have been advances in personalized therapy directed by molecular profiles in lung adenocarcinoma, but not in lung squamous cell carcinoma (SCC). The lack of actionable driver oncogenes in SCC has restricted the use of… read more here.
Keywords: cell carcinoma; squamous cell; belinostat; cytotoxicity ... See more keywords
The NRF2 antagonist ML385 inhibits PI3K‐mTOR signaling and growth of lung squamous cell carcinoma cells
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5311
Abstract: Lung squamous cell carcinoma (LUSC) currently has limited therapeutic options because of the relatively few validated targets and the lack of clinical drugs for some of these targets. Although NRF2/NFE2L2 pathway activation commonly occurs in… read more here.
Keywords: ml385; cell carcinoma; squamous cell; lung squamous ... See more keywords
NKX2‐1 Restricts the Growth and Metastasis of Lung Squamous Cell Carcinoma Through Transcriptive Suppression of AKR1B10
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70507
Abstract: Lung squamous cell carcinoma (LUSC) is associated with poor prognosis and limited treatment options. In this study, we investigate the role of NKX2‐1 as a tumor suppressor in LUSC. Our analysis of The Cancer Genome… read more here.
Keywords: lung; growth metastasis; cell; squamous cell ... See more keywords
The genomic alterations of lung adenocarcinoma and lung squamous cell carcinoma can explain the differences of their overall survival rates
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27917
Abstract: In the US, lung carcinoma accounted for over 150,000 deaths in 2018 and the advances in increasing survival rates are still limited. In this study, we investigated the cohorts with lung adenocarcinoma (LUAD) or lung… read more here.
Keywords: lung adenocarcinoma; genomic alterations; carcinoma; survival rates ... See more keywords
Dysregulated Th1 cells in lung squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1ma0422-208r
Abstract: Lung squamous cell carcinoma (LUSC) is a common subtype of lung cancer. Th1 cells contribute to antitumor immune responses. However, there are few studies on Th1 cells in LUSC. CD8+ T cells are the main… read more here.
Keywords: cell carcinoma; th1; th1 cells; squamous cell ... See more keywords
Pyroptosis‐related gene GSDMC indicates poor prognosis and promotes tumor progression by activating the AKT/mTOR pathway in lung squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23805
Abstract: Lung squamous cell carcinoma (LUSC) is one of the most common malignant tumors of the respiratory. Pyroptosis plays an essential role in cancer, but there is limited research investigating pyroptosis in LUSC. In this study,… read more here.
Keywords: pyroptosis; akt mtor; squamous cell; gsdmc ... See more keywords
A lung squamous carcinoma patient with ROS1 rearrangement sensitive to crizotinib
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-018-3660-2
Abstract: It is widely known that ROS1 rearrangement mostly occurs in the adenocarcinoma subtype of non-small-cell lung cancer. Patients with squamous cell carcinoma harboring ROS1 rearrangement are extremely rare. This is a case report of a… read more here.
Keywords: lung squamous; ros1 rearrangement; carcinoma patient; carcinoma ... See more keywords
Prognostic and therapeutic potential of copper-induced cell death-related lncRNAs in lung squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-025-01663-6
Abstract: Lung squamous cell carcinoma (LUSC), a major subtype of non-small cell lung cancer, remains challenging to treat due to poor prognosis and limited therapeutic options. This study investigates the prognostic and therapeutic implications of copper-induced… read more here.
Keywords: risk; cell; squamous cell; cell carcinoma ... See more keywords
LINC00885 promotes lung squamous cell carcinoma by upregulating SLBP expression to activate PI3K/Akt pathway
Sign Up to like & getrecommendations! Published in 2025 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-025-01863-0
Abstract: Lung squamous cell carcinoma (LUSC) remains an aggressive malignancy with limited therapeutic options and poor prognosis. Understanding the molecular drivers of LUSC pathogenesis is crucial for developing novel interventions. This study investigates the functional significance… read more here.
Keywords: linc00885; squamous cell; cell carcinoma; lung squamous ... See more keywords
Machine learning identifies 10 feature miRNAs for Lung squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144669
Abstract: Lung squamous cell carcinoma (LUSC) is a common type of malignancy. The mechanism behind its tumor progression is not clear yet. The aim of this study is to use machine learning to identify the feature… read more here.
Keywords: carcinoma; mir; squamous cell; feature mirnas ... See more keywords
Identification and validation of Osteopontin and receptor for hyaluronic acid-mediated motility (RHAMM, CD168) for potential immunotherapeutic significance of in lung squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108715
Abstract: BACKGROUND Lung cancer is the leading cause of cancer-related deaths. Immunotherapy is a promising therapeutic approach, but the population best suited to immunotherapy is yet to be determined. MATERIALS AND METHODS Lung squamous cell carcinoma… read more here.
Keywords: cell carcinoma; squamous cell; receptor; lung squamous ... See more keywords