Drug Meets Monolayer: Understanding the Interactions of Sterol Drugs with Models of the Lung Surfactant Monolayer Using Molecular Dynamics Simulations.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1843-1_9
Abstract: The lung surfactant monolayer (LSM) is a thin layer of lipids and proteins that forms the air/water interface of the alveoli. The primary function of the LSM is to reduce the surface tension at the… read more here.
Keywords: lung surfactant; drug; monolayer; surfactant monolayer ... See more keywords
Clinical, technological, and economic issues associated with developing new lung surfactant therapeutics.
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology advances"
DOI: 10.1016/j.biotechadv.2018.03.017
Abstract: Discovery of lung surfactant deficiency as a main cause of neonatal respiratory distress syndrome (NRDS) has influenced a steep increase in lung surfactant research. Although this has yielded impactful scientific discoveries, much of the basic… read more here.
Keywords: clinical technological; technological economic; lung surfactant; lung surfactants ... See more keywords
Delivery of Lung Surfactant SP-C Based Nanostructures to Respiratory Air-Liquid Interfacial Films
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2116
Abstract: The breathing function is sustained by Lung Surfactant (LS), a macromolecular complex lining the alveolar air-liquid interface. In the context of the physiology of the LS system, the absence or dysfunction of surfactant protein SP-C… read more here.
Keywords: air; air liquid; respiratory air; lung surfactant ... See more keywords
Divide & Conquer: Surfactant Protein SP-C and Cholesterol Modulate Phase Segregation in Lung Surfactant.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.06.059
Abstract: Lung surfactant (LS) is an essential system supporting the respiratory function. Cholesterol can be deleterious for LS function, a condition that is reversed by the presence of the lipopeptide SP-C. In this work, the structure… read more here.
Keywords: surfactant protein; phase; cholesterol; lung surfactant ... See more keywords
Biophysical analysis of gelatin and PLGA nanoparticle interactions with complex biomimetic lung surfactant models
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra02859j
Abstract: Biocompatible materials are increasingly used for pulmonary drug delivery, and it is essential to understand their potential impact on the respiratory system, notably their effect on lung surfactant, a monolayer of lipids and proteins, responsible… read more here.
Keywords: impact; lung; lung surfactant; gelatin ... See more keywords
Reply to the 'Comment on "Bilayer aggregate microstructure determines viscoelasticity of lung surfactant suspensions"' by J.-F. Berret, DOI: 10.1039/d2sm00653g.
Sign Up to like & getrecommendations! Published in 2022 at "Soft matter"
DOI: 10.1039/d2sm01142e
Abstract: In their comment, Berret suggests that Curosurf, one of three clinical lung surfactant aqueous suspensions examined in the Soft Matter, 2021, 17, 5170-51820 is a Newtonian liquid rather than a shear-thinning soft solid with a… read more here.
Keywords: comment bilayer; lung surfactant; reply comment; comment ... See more keywords
Shape matters—the interaction of gold nanoparticles with model lung surfactant monolayers
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2021.0402
Abstract: The lung surfactant monolayer (LSM) forms the main biological barrier for any inhaled particles to enter our bloodstream, including gold nanoparticles (AuNPs) present as air pollutants and under investigation for use in biomedical applications. Understanding… read more here.
Keywords: state; gold nanoparticles; shape; monolayer ... See more keywords
Aerosol Delivery of Lung Surfactant and Nasal CPAP in the Treatment of Neonatal Respiratory Distress Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2022.923010
Abstract: After shifting away from invasive mechanical ventilation and intratracheal instillation of surfactant toward non-invasive ventilation with nasal CPAP and less invasive surfactant administration in order to prevent bronchopulmonary dysplasia in preterm infants with respiratory distress… read more here.
Keywords: lung; non invasive; lung surfactant; nasal cpap ... See more keywords
Fluid Films as Models for Understanding the Impact of Inhaled Particles in Lung Surfactant Layers
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DOI: 10.3390/coatings12020277
Abstract: Pollution is currently a public health problem associated with different cardiovascular and respiratory diseases. These are commonly originated as a result of the pollutant transport to the alveolar cavity after their inhalation. Once pollutants enter… read more here.
Keywords: films models; lung surfactant; models understanding; understanding impact ... See more keywords
Aerosol–Cell Exposure System Applied to Semi-Adherent Cells for Aerosolization of Lung Surfactant and Nanoparticles Followed by High Quality RNA Extraction
Sign Up to like & getrecommendations! Published in 2022 at "Nanomaterials"
DOI: 10.3390/nano12081362
Abstract: Nanoparticle toxicity assessments have moved closer to physiological conditions while trying to avoid the use of animal models. An example of new in vitro exposure techniques developed is the exposure of cultured cells at the… read more here.
Keywords: system; adherent cells; semi adherent; lung surfactant ... See more keywords