Nrf2-activated expression of sulfiredoxin contributes to urethane-induced lung tumorigenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.06.011
Abstract: Lung cancer is the leading cause of cancer death worldwide. Cigarette smoking and exposure to chemical carcinogens are among the risk factors of lung tumorigenesis. In this study, we found that cigarette smoke condensate and… read more here.
Keywords: expression sulfiredoxin; srx; cancer; lung tumorigenesis ... See more keywords
Is NLRP3 or NLRP6 inflammasome activation associated with inflammation-related lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide?
Sign Up to like & getrecommendations! Published in 2019 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2019.109687
Abstract: Chronic inflammation has been shown to play a vital role in lung tumorigenesis. Recently, we have successfully developed a C57BL/6 mouse model of inflammation-related lung tumorigenesis induced by benzo(a)pyrene [B(a)p] and lipopolysaccharide (LPS), which will… read more here.
Keywords: inflammation related; nlrp3 nlrp6; lung tumorigenesis;
Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-3214
Abstract: Loss of RBMS3 cooperates with BRAFV600E to induce lung tumorigenesis, providing a deeper understanding of the molecular mechanisms underlying mutant BRAF-driven lung cancer and potential strategies to more effectively target this disease. read more here.
Keywords: transposon mutagenesis; mutagenesis reveals; driven lung; lung tumorigenesis ... See more keywords
Loss of MLL induces epigenetic dysregulation of Rasgrf1 to attenuate Kras-driven lung tumorigenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-1475
Abstract: Menin is necessary for the formation of the menin/MLL complex and is recruited directly to chromatin. Menin is an important tumor suppressor in several cancer types, including lung cancer. Here, we investigated the role of… read more here.
Keywords: rasgrf1; menin; lung tumorigenesis; cancer ... See more keywords
Abstract 1094: Lipopolysaccharide-induced chronic inflammation promotes lung tumorigenesis in the context of an immunosuppressive microenvironment
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-1094
Abstract: Clinical and epidemiological evidence suggest that chronic infection and inflammation increase risk of lung cancer. Pseudomonas aeruginosa infection is frequently found in patients with chronic obstructive pulmonary disease (COPD) and is associated with increased lung… read more here.
Keywords: lung; treatment; lps nnk; lung tumorigenesis ... See more keywords
Abstract LB228: PD-L1/PD-1 and arsenic lung tumorigenesis
Sign Up to like & getrecommendations! Published in 2021 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2021-lb228
Abstract: Chronic exposure of environmental arsenic promotes lung cancer. Emerging evidence indicates that compromised host immunity, particularly T cell anti-tumor immunity, may play a critical role in cancer development. However, there is a knowledge gap in… read more here.
Keywords: anti tumor; lung; cancer; lung tumorigenesis ... See more keywords
Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-21-0905
Abstract: Abstract Caspase 9 undergoes alternative splicing to produce two opposing isoforms: proapoptotic Caspase 9a and pro-survival Caspase 9b (C9b). Previously, our laboratory reported that C9b is expressed in majority of non–small cell lung cancer tumors… read more here.
Keywords: lung; c9b; lung inflammation; lung tumorigenesis ... See more keywords
Selective targeting of KRAS-driven lung tumorigenesis via unresolved ER stress
Sign Up to like & getrecommendations! Published in 2021 at "JCI Insight"
DOI: 10.1172/jci.insight.137876
Abstract: Lung cancer with oncogenic KRAS makes up a significant proportion of lung cancers and is accompanied by a poor prognosis. Recent advances in understanding the molecular pathogenesis of lung cancer with oncogenic KRAS have enabled… read more here.
Keywords: driven lung; lung cancer; kras driven; lung tumorigenesis ... See more keywords
Aminoacyl-tRNA synthetases, the indispensable players in Lung tumorigenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Protein and peptide letters"
DOI: 10.2174/0929866529666220110143520
Abstract: Being an essential enzyme in protein synthesis, the aminoacyl-tRNA synthetases (aaRSs) have a conserved function throughout evolution. However, research has uncovered alteredexpressions as well as interactions of aaRSs, in league with aaRS-interacting multi-functional proteins (AIMPs),… read more here.
Keywords: synthetases indispensable; tumorigenesis; indispensable players; trna synthetases ... See more keywords