Seco-Lupane Triterpene Derivatives Induce Ferroptosis through GPX4/ACSL4 Axis and Target Cyclin D1 to Block the Cell Cycle.
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DOI: 10.1021/acs.jmedchem.2c00664
Abstract: In this study, 70 new seco-lupane triterpene derivatives were designed, synthesized, and characterized, and their in vitro anticancer activities were evaluated. Structure-activity relationship studies showed that most compounds inhibited the growth of a variety of… read more here.
Keywords: cycle; triterpene derivatives; cell cycle; lupane triterpene ... See more keywords
3,4-seco-lupane triterpene derivatives with cytotoxic activities from the leaves of Eleutherococcus sessiliflorus
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DOI: 10.1080/14786419.2019.1656622
Abstract: Abstract A new 3,4-seco-lupane triterpene, named sessiligenin (1), along with four known 3,4-seco-lupane triterpene derivatives (chiisanogenin 2, chiisanoside 3, divaroside 4, and sessiliside-A1 5) were isolated from the ethanol extract of the leaves of Eleutherococcus… read more here.
Keywords: leaves eleutherococcus; lupane triterpene; triterpene derivatives; seco lupane ... See more keywords