Anti-domain 1 of beta2-glycoprotein I aids risk stratification in lupus anticoagulant-positive patients
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DOI: 10.1007/s10238-019-00555-w
Abstract: Lupus anticoagulant (LA) is considered a risk factor for thromboembolism (TE) and adverse pregnancy outcomes (APOs). However, quite a few patients diagnosed with LA positivity do not suffer these adverse events. Further testing of anticardiolipin… read more here.
Keywords: risk; positive patients; beta2 glycoprotein; anti domain ... See more keywords
Antiphospholipid antibody profile based obstetric outcomes of primary antiphospholipid syndrome: the PREGNANTS study
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DOI: 10.1016/j.ajog.2017.01.026
Abstract: BACKGROUND: Antiphospholipid syndrome is an autoimmune, hypercoagulable state that is caused by antiphospholipid antibodies. Anticardiolipin antibodies, anti‐&bgr;2 glycoprotein‐I, and lupus anticoagulant are the main autoantibodies found in antiphospholipid syndrome. Despite the amassed body of clinical… read more here.
Keywords: primary antiphospholipid; antiphospholipid syndrome; antibody; lupus anticoagulant ... See more keywords
Detection of lupus anticoagulant in the era of direct oral anticoagulants.
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DOI: 10.1016/j.autrev.2016.12.010
Abstract: Lupus anticoagulant (LAC) is an in vitro phenomenon determining a phospholipid-dependent elongation of clotting times. The presence of LAC associated with anticardiolipin (aCL) and anti-β2 glycoprotein I (anti-β2GPI) antibodies is strongly associated with thrombosis and… read more here.
Keywords: oral anticoagulants; direct oral; false positive; lac ... See more keywords
Prevalence of Antiphospholipid Antibody Positivity and Association of Pretransplant Lupus Anticoagulant Positivity With Early Allograft Dysfunction in Liver Transplantation.
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DOI: 10.1016/j.transproceed.2018.02.034
Abstract: BACKGROUND Antiphospholipid antibodies (aPL), including anticardiolipin (aCL), anti-β2-glycoprotein I (anti-β2GPI), and lupus anticoagulant (LA) antibodies, are frequently found in liver cirrhosis and associated with splanchnic vein thrombosis. Although the risk factors of early allograft dysfunction… read more here.
Keywords: ead; positivity; prevalence; association ... See more keywords
An Extremely Rare Cause of Prolonged Menstruation: Lupus Anticoagulant-Hypoprothrombinemia Syndrome
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DOI: 10.1080/01443615.2019.1637406
Abstract: Lupus anticoagulant hypoprothrombinaemia syndrome (LACHPS) is a rare disorder, defined by the presence of an acquired factor II (FII) deficiency and lupus anticoagulant (LAC) (Rapaport et al. 1960). The main symptom is bleeding that may… read more here.
Keywords: extremely rare; lupus; cause prolonged; syndrome ... See more keywords
The Effects of Indirect- and Direct-Acting Anticoagulants on Lupus Anticoagulant Assays: A Large, Retrospective Study at a Coagulation Reference Laboratory
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DOI: 10.1093/ajcp/aqx035
Abstract: Objectives To investigate the effects of indirect- and direct-acting anticoagulants on the interpretation of lupus anticoagulant (LAC) assays. Methods A retrospective database review was performed to identify all LAC panels from November 2012 to November… read more here.
Keywords: indirect direct; effects indirect; direct acting; lac ... See more keywords
Paired APTTs of low and high lupus anticoagulant sensitivity permit distinction from other abnormalities and achieve good lupus anticoagulant detection rates in conjunction with dRVVT
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DOI: 10.1111/ijlh.12921
Abstract: A prolonged activated partial thromboplastin time (APTT) may be indicative of a specific or multiple factor deficiency, therapeutic anticoagulation, presence of a nonspecific factor inhibitor, or lupus anticoagulant (LA). Recently, pairing of the LA‐sensitive APTT… read more here.
Keywords: detection; aptts low; low high; lupus ... See more keywords
Lupus anticoagulant is frequent in patients with Covid‐19
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DOI: 10.1111/jth.14867
Abstract: Patients hospitalized for Covid-19 severe infection are more prone to excessive coagulation activation leading to thrombotic events. Tang et al.1 discussed the importance of high D-dimer and Fibrin degradation product level to determine the patient… read more here.
Keywords: patients covid; anticoagulant frequent; lupus anticoagulant; frequent patients ... See more keywords
Response to “Lupus anticoagulant is frequent in patients with Covid‐19”
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DOI: 10.1111/jth.14890
Abstract: Abstract We appreciate the opportunity to respond to the letter from Dr. Inès Harzallah, et al. Antiphospholipid antibody assays including lupus anticoagulant (LAC), anticardiolipin and anti–β2‐glycoprotein I have also been performed in dozens of our… read more here.
Keywords: anticoagulant frequent; frequent patients; response lupus; patients covid ... See more keywords
Guidance from the Scientific and Standardization Committee for lupus anticoagulant/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis
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DOI: 10.1111/jth.15047
Abstract: This guidance focuses on methodological aspects of lupus anticoagulant (LA) testing, as well as interpretation of results for clinicians. The main changes in how to test for LA compared with the International Society on Thrombosis… read more here.
Keywords: international society; society thrombosis; thrombosis haemostasis; thrombosis ... See more keywords
Added value of antiphosphatidylserine/prothrombin antibodies in the workup of thrombotic antiphospholipid syndrome: Communication from the ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies
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DOI: 10.1111/jth.15785
Abstract: Diagnosis of antiphospholipid syndrome (APS) requires persistent presence of lupus anticoagulant (LAC), anticardiolipin (aCL) IgG/IgM, or anti‐β2 glycoprotein I (aβ2GPI) IgG/IgM antibodies. Other antiphospholipid antibodies (aPL) such as antiphosphatidylserine/prothrombin antibodies (aPS/PT) are promising in assessment… read more here.
Keywords: antiphosphatidylserine prothrombin; antiphospholipid syndrome; prothrombin antibodies; lupus anticoagulant ... See more keywords