MicroRNA-590-3p inhibits T helper 17 cells and ameliorates inflammation in lupus mice.
Sign Up to like & getrecommendations! Published in 2021 at "Immunology"
DOI: 10.1111/imm.13434
Abstract: T helper 17 (Th17) cells have a pathogenic effect in many autoimmune diseases. Inhibition of Th17 cells can alleviate the inflammatory damage in autoimmune diseases. Our previous study found that microRNA-590-3p (miR-590-3p) was involved in… read more here.
Keywords: mir 590; th17 cells; lupus mice; th17 ... See more keywords
Zetomipzomib (KZR-616) attenuates lupus in mice via modulation of innate and adaptive immune responses
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1043680
Abstract: Zetomipzomib (KZR-616) is a selective inhibitor of the immunoproteasome currently undergoing clinical investigation in autoimmune disorders. Here, we characterized KZR-616 in vitro and in vivo using multiplexed cytokine analysis, lymphocyte activation and differentiation, and differential… read more here.
Keywords: 616 attenuates; mice via; kzr 616; zetomipzomib kzr ... See more keywords
Perivascular adipose tissue promotes vascular dysfunction in murine lupus
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1095034
Abstract: Introduction Patients with systemic lupus erythematosus (SLE) are at elevated risk for Q10 cardiovascular disease (CVD) due to accelerated atherosclerosis. Compared to heathy control subjects, lupus patients have higher volumes and densities of thoracic aortic… read more here.
Keywords: vascular dysfunction; pvat; adipose tissue; lupus mice ... See more keywords