Effect of Tacrolimus vs Intravenous Cyclophosphamide on Complete or Partial Response in Patients With Lupus Nephritis
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DOI: 10.1001/jamanetworkopen.2022.4492
Abstract: Key Points Question What is the efficacy and safety of tacrolimus vs intravenous cyclophosphamide (IVCY) as initial therapy for lupus nephritis (LN) among Chinese patients? Findings In this randomized clinical trial of 299 patients, the… read more here.
Keywords: tacrolimus intravenous; lupus nephritis; complete partial; tacrolimus ... See more keywords
Dual immuno-renal targeting of 7-benzylidenenaltrexone alleviates lupus nephritis via FcγRIIB and HO-1
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DOI: 10.1007/s00109-018-1626-9
Abstract: Known as a selective δ1 opioid receptor (DOR1) antagonist, the 7-benzylidenenaltrexone (BNTX) is also a DOR1-independent immunosuppressant with unknown mechanisms. Here we investigated if BNTX could be beneficial for diseased MRL/lpr lupus mice. We treated… read more here.
Keywords: p38 mapk; benzylidenenaltrexone; via riib; lupus nephritis ... See more keywords
Clinical presentation and outcomes of childhood-onset membranous lupus nephritis
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DOI: 10.1007/s00467-017-3743-z
Abstract: BackgroundBest practices for managing childhood-onset membranous lupus nephritis (MLN) are not yet established. Most studies involve primarily or exclusively adult cohorts or pediatric cohorts with combinations of pure or mixed membranous and proliferative nephritis.MethodsWe performed… read more here.
Keywords: membranous lupus; onset membranous; childhood onset; lupus nephritis ... See more keywords
Combination therapy of rituximab and mycophenolate mofetil in childhood lupus nephritis
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DOI: 10.1007/s00467-017-3767-4
Abstract: BackgroundIn clinical trials, the addition of rituximab (RTX) to the combination therapeutic regimen of mycophenolate mofetil (MMF) and corticosteroids failed to improve outcome in lupus nephritis (LN). However, recent data suggest that RTX may have… read more here.
Keywords: rituximab; combination; lupus nephritis; rtx ... See more keywords
Twelve-month outcome in juvenile proliferative lupus nephritis: results of the German registry study
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DOI: 10.1007/s00467-020-04501-x
Abstract: Background Children presenting with proliferative lupus nephritis (LN) are treated with intensified immunosuppressive protocols. Data on renal outcome and treatment toxicity is scare. Methods Twelve-month renal outcome and comorbidity were assessed in 79 predominantly Caucasian… read more here.
Keywords: lupus nephritis; nephrology; renal outcome; proliferative lupus ... See more keywords
Mycophenolic acid area under the concentration-time curve is associated with therapeutic response in childhood-onset lupus nephritis
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DOI: 10.1007/s00467-020-04733-x
Abstract: Background Mycophenolic acid (MPA), the active compound of mycophenolate mofetil (MMF), is widely used in lupus nephritis treatment. Therapeutic drug monitoring of adults suggests that area under the concentration-time curve (AUC) of MPA (MPA-AUC) is… read more here.
Keywords: lupus nephritis; mpa auc; time; response ... See more keywords
Steroid treatment promotes an M2 anti-inflammatory macrophage phenotype in childhood lupus nephritis
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DOI: 10.1007/s00467-020-04734-w
Abstract: Background M1-type proinflammatory macrophages (MΦ) promote glomerular injury in lupus nephritis (LN). However, whether this phenotype is altered by steroid therapy is unclear. Therefore, we investigated the effect of steroid treatment on MΦ phenotype in… read more here.
Keywords: anti inflammatory; phenotype; steroid treatment; treatment ... See more keywords
Impact of pre-transplant time on dialysis on survival in patients with lupus nephritis
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DOI: 10.1007/s10067-018-4115-1
Abstract: Lupus nephritis (LN) is an important cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE) often leading to end-stage renal failure (ESRF) and necessitating renal transplantation (rTp). Optimal timing of rTp in… read more here.
Keywords: time; patients lupus; lupus nephritis; time dialysis ... See more keywords
Non-albumin proteinuria as a parameter of tubulointerstitial inflammation in lupus nephritis
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DOI: 10.1007/s10067-018-4256-2
Abstract: Tubulointerstitial inflammation (TI) has prognostic significance in the renal outcomes of lupus nephritis. Here, we aimed to determine whether non-albumin proteinuria is associated with TI severity and with the renal response in lupus nephritis. We… read more here.
Keywords: lupus nephritis; non albumin; albumin proteinuria;
Treatment of pediatric-onset lupus nephritis: a proposal of optimal therapy
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DOI: 10.1007/s10157-017-1381-1
Abstract: Lupus nephritis (LN) is one of the major clinical manifestations of systemic lupus erythematosus (SLE) which occurs frequently in the early stages of pediatric-onset cases. Since SLE is a chronic disease associated with frequent disease… read more here.
Keywords: therapy; lupus nephritis; treatment; pediatric onset ... See more keywords
UCH-L1 Expressed by Podocytes: a Potentially Therapeutic Target for Lupus Nephritis?
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DOI: 10.1007/s10753-017-0512-x
Abstract: Systemic lupus erythematosus (SLE) is a multisystem disease affecting many organs, and the most severe complication is lupus nephritis. Podocyte injury and loss play vital roles in the pathogenesis of lupus nephritis. Studies have shown… read more here.
Keywords: expressed podocytes; lupus nephritis; uch expressed; lupus ... See more keywords