Ultraviolet light induces increased T cell activation in lupus-prone mice via type I IFN-dependent inhibition of T regulatory cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2019.06.002
Abstract: Ultraviolet (UV) light is a known trigger of skin and possibly systemic inflammation in systemic lupus erythematosus (SLE) patients. Although type I interferons (IFN) are upregulated in SLE skin after UV exposure, the mechanisms to… read more here.
Keywords: lupus prone; type ifn; mice; prone mice ... See more keywords
Micelle-Forming Dexamethasone Prodrug Attenuates Nephritis in Lupus-Prone Mice without Apparent Glucocorticoid Side Effects
Sign Up to like & getrecommendations! Published in 2018 at "ACS Nano"
DOI: 10.1021/acsnano.8b01249
Abstract: Nephritis is one of the major complications of systemic lupus erythematosus. While glucocorticoids (GCs) are frequently used as the first-line treatment for lupus nephritis (LN), long-term GC usage is often complicated by severe adverse effects.… read more here.
Keywords: zsj 0228; lupus prone; treatment; zsj ... See more keywords
Upadacitinib in MTX-naive RA
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-020-0479-0
Abstract: Changes in the gut microbiota have previously been associated with systemic lupus erythematosus (SLE) in humans and in mouse models of the disease, as have changes in the metabolism of tryptophan, which requires microbial involvement.… read more here.
Keywords: tryptophan; lupus prone; mice; prone mice ... See more keywords
Preclinical stage abundance and nuclear antigen reactivity of faecal Immunoglobulin A vary among males and females of lupus‐prone mouse models
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13459
Abstract: Systemic lupus erythematosus (SLE) is characterized by the production of pathogenic autoantibodies with nuclear antigen (nAg) specificity. Using (SWRxNZB)F1 (SNF1) mice, we showed higher levels of Immunoglobulin A (IgA) production in the intestine and the… read more here.
Keywords: lupus prone; nag reactivity; reactivity; faecal iga ... See more keywords
THU0223 THE NEUROPSYCHIATRIC PHENOTYPE OF NZB/W LUPUS-PRONE MOUSE MODEL AT PRE-NEPHRITIC AND NEPHRITIC STAGES OF THE DISEASE: MURINE MODEL RECAPITULATES HUMAN DISEASE
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.1807
Abstract: The pathogenesis of neuropsychiatric lupus (NPSLE) remains ill-defined due to limited access to tissue and the diversity and complexity of clinical manifestations with most evidence deriving from animal studies in MLR/lpr lupus-prone mouse.To phenotype and… read more here.
Keywords: lupus; test; lupus prone; model ... See more keywords
Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice
Sign Up to like & getrecommendations! Published in 2021 at "JCI Insight"
DOI: 10.1172/jci.insight.143245
Abstract: Autoimmune disease has presented an insurmountable barrier to restoration of durable immune tolerance. Previous studies indicate that chronic therapy with metabolic inhibitors can reduce autoimmune inflammation, but it remains unknown whether acute metabolic modulation enables… read more here.
Keywords: tolerance; immune tolerance; lupus prone; prone mice ... See more keywords
Oxidized Hemoglobin Is Antigenic and Immunogenic in Lupus
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00732
Abstract: Hemolysis-associated anemia is characteristic of diseases such as atherosclerosis, lupus, malaria, and leishmaniasis; the toxic effects of free hemoglobin (Hb) have been extensively described. This study was based on the premise that release of this… read more here.
Keywords: lupus prone; oxidized hemoglobin; prone mice; lupus ... See more keywords
Rapid Induction of Pulmonary Inflammation, Autoimmune Gene Expression, and Ectopic Lymphoid Neogenesis Following Acute Silica Exposure in Lupus-Prone Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.635138
Abstract: Occupational exposure to crystalline silica (cSiO2) is etiologically associated with systemic lupus erythematosus (lupus) and other autoimmune diseases. cSiO2's autoimmune effects in humans can be mimicked chronically in female lupus-prone NZBWF1 mice following repeated exposure… read more here.
Keywords: lupus prone; inflammation; exposure; csio2 ... See more keywords
Silica Induction of Diverse Inflammatory Proteome in Lungs of Lupus-Prone Mice Quelled by Dietary Docosahexaenoic Acid Supplementation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.781446
Abstract: Repeated short-term intranasal instillation of lupus-prone mice with crystalline silica (cSiO2) induces inflammatory gene expression and ectopic lymphoid neogenesis in the lung, leading to early onset of systemic autoimmunity and rapid progression to glomerulonephritis. These… read more here.
Keywords: prone mice; supplementation; dha; lupus prone ... See more keywords
Human Umbilical Cord Mesenchymal Stem Cells Inhibit T Follicular Helper Cell Expansion through the Activation of iNOS in Lupus-Prone B6.MRL-Faslpr Mice
Sign Up to like & getrecommendations! Published in 2017 at "Cell Transplantation"
DOI: 10.3727/096368917x694660
Abstract: The aberrant generation or activation of T follicular helper (Tfh) cells contributes to the pathogenesis of systemic lupus erythematosus (SLE), yet little is known about how these cells are regulated. In this study, we demonstrated… read more here.
Keywords: huc mscs; lupus prone; tfh cells; activation ... See more keywords