Enhanced oral bioavailability and diminished food effect of lurasidone hydrochloride nanosuspensions prepared by facile nanoprecipitation based on dilution
Sign Up to like & getrecommendations! Published in 2017 at "Powder Technology"
DOI: 10.1016/j.powtec.2017.02.038
Abstract: Abstract The aim of this study was to improve the oral bioavailability and diminish the food effect of a poorly soluble drug with pH-dependent solubility, lurasidone hydrochloride (LH), by fabricating its nanosuspensions using a facile… read more here.
Keywords: oral bioavailability; food effect; bioavailability; facile nanoprecipitation ... See more keywords
Improving Lurasidone Hydrochloride’s Solubility and Stability by Higher-Order Complex Formation with Hydroxypropyl-β-cyclodextrin
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DOI: 10.3390/pharmaceutics15010232
Abstract: The biopharmaceutical classification system groups low-solubility drugs into two groups: II and IV, with high and low permeability, respectively. Most of the new drugs developed for common pathologies present solubility issues. This is the case… read more here.
Keywords: lurasidone hydrochloride; hydroxypropyl cyclodextrin; solubility; solubility stability ... See more keywords