The effect of luteolin in prevention of periodontal disease in Wistar rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of periodontology"
DOI: 10.1002/jper.18-0584
Abstract: BACKGROUND Periodontal disease is the chronic infectious disease of the periodontium. Because of irreversibility, prevention of disease is one of the most important goals of periodontal treatment. The aim of this study was to evaluate… read more here.
Keywords: prevention; luteolin; cell; disease ... See more keywords
Stimulation of Fas/FasL‐mediated apoptosis by luteolin through enhancement of histone H3 acetylation and c‐Jun activation in HL‐60 leukemia cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22807
Abstract: Luteolin (3′,4′,5,7‐tetrahydroxyflavone), which exists in fruits, vegetables, and medicinal herbs, is used in Chinese traditional medicine for treating various diseases, such as hypertension, inflammatory disorders, and cancer. However, the gene‐regulatory role of luteolin in cancer… read more here.
Keywords: histone acetylation; acetylation; jun; fas fasl ... See more keywords
A physiological concentration of luteolin induces phase II drug-metabolizing enzymes through the ERK1/2 signaling pathway in HepG2 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.01.012
Abstract: The flavon luteolin has various health-promoting activities including cardiovascular protection, anti-inflammatory activity and anticancer activity. A serum concentration of about 100 nM luteolin is reached by dietary habit. However, little is known about the function of… read more here.
Keywords: drug metabolizing; phase drug; physiological concentration; metabolizing enzymes ... See more keywords
Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin
Sign Up to like & getrecommendations! Published in 2017 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.03.026
Abstract: Abstract In many countries afflicted with dengue fever, traditional medicines are widely used as panaceas for illness, and here we describe the systematic evaluation of a widely known natural product, luteolin, originating from the “heat… read more here.
Keywords: dengue virus; convertase furin; inhibition; luteolin ... See more keywords
Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.04.013
Abstract: ABSTRACT We previously showed that luteolin, a well‐known plant‐derived component found in the “heat clearing” class of Traditional Chinese Medicine (TCM) herbs, is an uncompetitive inhibitor (Ki 58.6&mgr;M) of the host proprotein convertase furin, an… read more here.
Keywords: escape mutants; luteolin; virus; ns2b i114m ... See more keywords
Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.05.019
Abstract: Upregulated expression of immune checkpoint molecules correlates with exhausted phenotype and impaired function of cytotoxic T cells to evade host immunity. By disrupting the interaction of PD-L1 and PD1, immune checkpoint inhibitors can restore immune… read more here.
Keywords: expression; kras mutant; lung cancer; cancer ... See more keywords
Luteolin and 5-flurouracil act synergistically to induce cellular weapons in experimentally induced Solid Ehrlich Carcinoma: Realistic role of P53; a guardian fights in a cellular battle.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.108740
Abstract: BACKGROUND Solid Ehrlich Carcinoma (SEC) is an undifferentiated tumor used in tumor studies and chemotherapy investigations. AIM to assess the anti-tumor potential of luteolin when used either alone or combined to 5-fluorouracil (5-FU) against SEC.… read more here.
Keywords: ehrlich carcinoma; solid ehrlich; p53; luteolin ... See more keywords
Growth, physiological responses and microcystin-production/-release dynamics of Microcystis aeruginosa exposed to various luteolin doses.
Sign Up to like & getrecommendations! Published in 2020 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2020.110540
Abstract: By testing time-dependent IC50 of luteolin against Microcystis growth, this study revealed 6.5 mg/L as nearly IC50 value during prolonged stress until day 14, and explored chlorophyll-a (CLA) and phycobiliproteins (PBPs) contents, antioxidant responses and microcystin… read more here.
Keywords: growth; production release; luteolin doses; luteolin ... See more keywords
ROS-independent inhibition of melanoma tumor growth by luteolin involves BRAF and the MAPK pathway
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.148
Abstract: Background Melanoma is a reactive oxygen species (ROS)-driven cancer but developing antioxidants as therapeutic drugs have not been successful. Methods We screened a number of antioxidants for their capacity of inhibiting melanoma cell growth and… read more here.
Keywords: growth; braf; inhibition; luteolin ... See more keywords
MiR-34a, as a suppressor, enhance the susceptibility of gastric cancer cell to luteolin by directly targeting HK1.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2017.10.046
Abstract: Luteolin is a flavonoid compound derived from Lonicera japonica Thunb, which has been reported to exert anticancer effects on different types of tumors. miRNAs are a kind of endogenous non-coding small RNAs, which involved in… read more here.
Keywords: susceptibility; cell; mir 34a; hk1 ... See more keywords
Effects of luteolin on treatment of psoriasis by repressing HSP90.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.106070
Abstract: AIMS This study was conducted to further clarify the efficacy and potential of luteolin in treating psoriasis and to explore its inner mechanisms. METHODS A pharmacology network displayed the construction of a drug disease target… read more here.
Keywords: hsp90; treatment psoriasis; pharmacology; expression ... See more keywords