Binding mode exploration of LuxR-thiazolidinedione analogues, e-pharmacophore-based virtual screening in the designing of LuxR inhibitors and its biological evaluation
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DOI: 10.1080/07391102.2016.1166455
Abstract: Master quorum sensing (QS) regulator LuxR of Vibrio harveyi is a unique member of the TetR protein superfamily. Recent studies have demonstrated the contribution of thiazolidinedione analogues in blocking QS by decreasing the DNA-binding ability… read more here.
Keywords: chembridge 5343641; thiazolidinedione analogues; mode exploration; binding mode ... See more keywords
QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species
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DOI: 10.1128/mbio.02262-17
Abstract: ABSTRACT Pathogenic Vibrio species cause diseases in diverse marine animals reared in aquaculture. Since their pathogenesis, persistence, and survival in marine environments are regulated by quorum sensing (QS), QS interference has attracted attention as a… read more here.
Keywords: selective inhibitor; vibrio; quorum sensing; vibrio species ... See more keywords
In silico Analysis Reveals Distribution of Quorum Sensing Genes and Consistent Presence of LuxR Solos in the Pandoraea Species
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DOI: 10.3389/fmicb.2019.01758
Abstract: The most common quorum sensing (QS) system in Gram-negative bacteria consists of signaling molecules called N-acyl-homoserine lactones (AHLs), which are synthesized by an enzyme AHL synthase (LuxI) and detected by a transcriptional regulator (LuxR) that… read more here.
Keywords: solos; presence; pandoraea species; luxr solos ... See more keywords