LXA4 enhances prostate cancer progression by facilitating M2 macrophage polarization via inhibition of METTL3.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108586
Abstract: Tumor-associated macrophages (TAMs) are major innate immune cells that play crucial roles in prostate cancer onset and progression. Recently, increasing evidence has suggested that elevated N6-adenine methylation of mRNA is observed in prostate cancer tissues… read more here.
Keywords: cancer; mettl3; progression; prostate cancer ... See more keywords
The therapeutic effects of lipoxin A4 during treadmill exercise on monosodium iodoacetate‐induced osteoarthritis in rats
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2018.08.027
Abstract: HIGHLIGHTSLXA4 was rapidly elevated and reduced to normal level after treadmill exercise.There was no difference of LXA4 between moderate and high intensity treadmill exercise.Moderate‐intensity treadmill exercise ameliorate OA could be suppressed by BOC‐2.LXA4 could attenuate… read more here.
Keywords: monosodium iodoacetate; lxa4; treadmill exercise; therapeutic effects ... See more keywords
Artesunate ameliorates osteoarthritis cartilage damage by updating MTA1 expression and promoting the transcriptional activation of LXA4 to suppress the JAK2/STAT3 signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac293
Abstract: OBJECTIVE The objective of this study was to discuss the mechanism of artesunate (ART) in improving cartilage damage in osteoarthritis (OA) by regulating the expression levels of MTA1, LXA4, and the downstream JAK2/STAT3 signaling pathway.… read more here.
Keywords: lxa4; signaling pathway; damage; stat3 signaling ... See more keywords
The protective effects of lipoxin A4 on type 2 diabetes mellitus: A Chinese prospective cohort study
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1109747
Abstract: Background Several cellular and animal studies have suggested that lipoxin A4 (LXA4) has a protective effect on type 2 diabetes mellitus (T2DM) development. However, little is known about whether LXA4 influences T2DM development at the… read more here.
Keywords: lxa4; t2dm development; type diabetes; diabetes mellitus ... See more keywords
Colorectal Cancer Is Associated with a Deficiency of Lipoxin A4, an Endogenous Anti-inflammatory Mediator
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer"
DOI: 10.7150/jca.32456
Abstract: Unresolved inflammation, due to insufficient production of proresolving anti-inflammatory lipid mediators, can lead to tumorigenesis. Among these mediators, lipoxin A4 (LXA4) has potent anti-carcinogenic properties, and may serve as key target for modulating inflammation-associated cancer… read more here.
Keywords: lxa4; colorectal cancer; cancer; cancer associated ... See more keywords