Nanoparticle-based "Two-pronged" approach to regress atherosclerosis by simultaneous modulation of cholesterol influx and efflux.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120333
Abstract: Reduction of lipoprotein uptake by macrophages and stimulation of cholesterol efflux are two essential steps required for atherosclerotic plaque regression. We used the optimized mannose-functionalized dendrimeric nanoparticle (mDNP)-based platform for macrophage-specific delivery of therapeutics to… read more here.
Keywords: lxr; two pronged; delivery; cholesterol ... See more keywords
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00175
Abstract: Reported as two antirenal cell carcinoma (RCC) drug candidates, marine-derived compounds piericidin A (PA) and glucopiericidin A (GPA) exhibit hepatotoxicity in renal carcinoma xenograft mice. Proteomics and transcriptomics reveal the hepatotoxicity related with cholesterol disposition… read more here.
Keywords: lxr; cholesterol; mice; cholesterol diet ... See more keywords
HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13835-w
Abstract: HIV patients develop hepatic steatosis. We investigated hepatic steatosis in transgenic mice expressing the HIV-1 accessory protein Vpr (Vpr-Tg) in liver and adipose tissues, and WT mice infused with synthetic Vpr. Vpr-Tg mice developed increased… read more here.
Keywords: lxr; fatty liver; vpr; mice ... See more keywords
Neuronal LXR Regulates Neuregulin 1 Expression and Sciatic Nerve-Associated Cell Signaling in Western Diet-fed Rodents
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-63357-1
Abstract: Neuropathic pain caused by peripheral nerve injuries significantly affects sensory perception and quality of life. Accumulating evidence strongly link cholesterol with development and progression of Obesity and Diabetes associated-neuropathies. However, the exact mechanisms of how… read more here.
Keywords: lxr; cell; expression; sensory neurons ... See more keywords
Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122683119
Abstract: Significance LXRs are critical regulators of hepatic metabolism and function, but their mechanisms of action at the genome level are incompletely understood. We performed integrated analysis of genome-wide chromatin accessibility, gene expression, and transcription factor… read more here.
Keywords: lxr binding; accessibility; lxr transcriptional; expression ... See more keywords
Liver X receptor: a potential target in the treatment of atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2117610
Abstract: ABSTRACT Introduction Liver X receptors (LXRs) are master regulators of atherogenesis. Their anti-atherogenic potential has been attributed to their role in the inhibition of macrophage-mediated inflammation and promotion of reverse cholesterol transport. Owing to the… read more here.
Keywords: atherosclerosis liver; liver receptor; lxr; lxr agonists ... See more keywords
Inhibition of protein arginine methyltransferase 3 activity selectively impairs liver X receptor‐driven transcription of hepatic lipogenic genes in vivo
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14361
Abstract: Agonists for the liver X receptor (LXR) are considered promising therapeutic moieties in cholesterol‐driven diseases by promoting cellular cholesterol efflux pathways. However, current clinical application of these agents is hampered by concomitant LXR‐induced activation of… read more here.
Keywords: protein arginine; liver receptor; lxr; arginine methyltransferase ... See more keywords
Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.155869
Abstract: HDL cholesterol (HDL-C) predicts risk of cardiovascular disease (CVD), but the factors regulating HDL are incompletely understood. Emerging data link CVD risk to decreased HDL-C in 8% of the world population and 40% of East… read more here.
Keywords: aldh2; hdl biogenesis; lxr; parp1 ... See more keywords
Modulation of LXR signaling altered the dynamic activity of human colon adenocarcinoma cancer stem cells in vitro
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cell International"
DOI: 10.1186/s12935-021-01803-4
Abstract: Background The expansion and metastasis of colorectal cancers are closely associated with the dynamic growth of cancer stem cells (CSCs). This study aimed to explore the possible effect of LXR (a regulator of glycolysis and… read more here.
Keywords: lxr; cancer stem; cd133 cells; cancer ... See more keywords
Epigenetic suppression of liver X receptor β in anterior cingulate cortex by HDAC5 drives CFA-induced chronic inflammatory pain
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1507-3
Abstract: BackgroundLiver X receptors (LXRs), including LXRα and LXRβ, are key regulators of transcriptional programs for both cholesterol homeostasis and inflammation in the brain. Here, the modes of action of LXRs and the epigenetic mechanisms regulating… read more here.
Keywords: lxr; inflammatory pain; chronic inflammatory; cingulate cortex ... See more keywords
Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Lipid Research"
DOI: 10.1194/jlr.m081851
Abstract: apoE is the primary lipid carrier within the CNS and the strongest genetic risk factor for late onset Alzheimer’s disease (AD). apoE is primarily lipidated via ABCA1, and both are under transcriptional regulation by the… read more here.
Keywords: lxr; abca1 apoe; small molecule; molecule inducers ... See more keywords