Discovery of Spiro[pyrrolidine-3,3'-oxindole] LXRβ Agonists for the Treatment of Osteoporosis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01661
Abstract: Osteoclasts have an additional demand for cholesterol compared to normal cells. Liver X receptors (LXRs) are famous for regulation of lipid and cholesterol metabolism. Therefore, we propose that the LXR β agonist can regulate the… read more here.
Keywords: pyrrolidine oxindole; lxr agonists; spiro pyrrolidine; osteoporosis ... See more keywords
Thrombomodulin activation driven by LXR agonist attenuates renal injury in diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.916620
Abstract: Objective Inflammation and thrombosis are recognized as interrelated biological processes. Both thrombomodulin (TM) and factor XIII-A (FXIII-A) are involved in inflammation and coagulation process. However, their role in the pathogenesis of diabetic nephropathy (DN) remains… read more here.
Keywords: renal injury; expression; lxr agonist; diabetic nephropathy ... See more keywords