Development of Light‐Activated LXR Agonists
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202200647
Abstract: Activation of the oxysterol‐sensing transcription factor liver X receptor (LXR) has been studied as a therapeutic strategy in metabolic diseases and cancer but is compromised by the side effects of LXR agonists. Local LXR activation… read more here.
Keywords: cancer; lxr agonists; activated lxr; development light ... See more keywords
Discovery of Spiro[pyrrolidine-3,3'-oxindole] LXRβ Agonists for the Treatment of Osteoporosis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01661
Abstract: Osteoclasts have an additional demand for cholesterol compared to normal cells. Liver X receptors (LXRs) are famous for regulation of lipid and cholesterol metabolism. Therefore, we propose that the LXR β agonist can regulate the… read more here.
Keywords: pyrrolidine oxindole; lxr agonists; spiro pyrrolidine; osteoporosis ... See more keywords
Liver X receptor: a potential target in the treatment of atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2117610
Abstract: ABSTRACT Introduction Liver X receptors (LXRs) are master regulators of atherogenesis. Their anti-atherogenic potential has been attributed to their role in the inhibition of macrophage-mediated inflammation and promotion of reverse cholesterol transport. Owing to the… read more here.
Keywords: atherosclerosis liver; liver receptor; lxr; lxr agonists ... See more keywords
Combining generative artificial intelligence and on-chip synthesis for de novo drug design
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abg3338
Abstract: Generative deep learning and miniaturized bench-top synthesis were combined to automate the design of novel LXR agonists. Automating the molecular design-make-test-analyze cycle accelerates hit and lead finding for drug discovery. Using deep learning for molecular… read more here.
Keywords: lxr agonists; drug; chip synthesis; synthesis ... See more keywords
Targeting macrophages in atherosclerosis using nanocarriers loaded with liver X receptor agonists: A narrow review
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1147699
Abstract: Macrophages are involved in the whole process of atherosclerosis, which is characterized by accumulation of lipid and inflammation. Presently, clinically used lipid-lowering drugs cannot completely retard the progress of atherosclerosis. Liver X receptor (LXR) plays… read more here.
Keywords: lxr agonists; macrophages atherosclerosis; nanocarriers loaded; atherosclerosis ... See more keywords