LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz747
Abstract: Abstract Activation of ribosomal RNA (rRNA) synthesis is pivotal during cell growth and proliferation, but its aberrant upregulation may promote tumorigenesis. Here, we demonstrate that the candidate oncoprotein, LYAR, enhances ribosomal DNA (rDNA) transcription. Our… read more here.
Keywords: lyar; rrna synthesis; rdna; kat7 ... See more keywords
LYAR suppresses interferon-β induction by targeting phosphorylated IRF3.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of virology"
DOI: 10.1128/jvi.00769-19
Abstract: The innate immune response is vital for host defense and must be tightly controlled, but the mechanisms responsible for its negative regulation have not been fully understood. The cell growth-regulating nucleolar protein (LYAR) has been… read more here.
Keywords: lyar; innate immune; irf3; immune responses ... See more keywords