Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1773314
Abstract: Abstract ATP citrate lyase (ACLY) is an important enzyme that catalyzes the conversion of citrate to acetyl-CoA in normal cells, facilitating the de novo fatty acid synthesis. Lipids and fatty acids were found to be… read more here.
Keywords: citrate lyase; atp citrate; citrate; pharmacophore based ... See more keywords
ATP-citrate lyase (ACLY) inhibitors as therapeutic agents: a patenting perspective
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2022.2067478
Abstract: ABSTRACT Introduction ATP citrate lyase (ACLY) is a key enzyme in cellular metabolism, being the main source of acetyl-Coenzyme A, an important precursor for fatty acid, cholesterol, and isoprenoid biosynthesis, and it is also involved… read more here.
Keywords: citrate lyase; lyase acly; acly; atp citrate ... See more keywords