12(S)-HETE induces lymph endothelial cell retraction in vitro by upregulation of SOX18.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of oncology"
DOI: 10.3892/ijo.2018.4378
Abstract: Metastasising breast cancer cells communicate with adjacent lymph endothelia, intravasate and disseminate through lymphatic routes, colonise lymph nodes and finally metastasize to distant organs. Thus, understanding and blocking intravasation may attenuate the metastatic cascade at… read more here.
Keywords: mda mb231; sox18; retraction; intravasation ... See more keywords
Feed‑back loops integrating RELA, SOX18 and FAK mediate the break‑down of the lymph‑endothelial barrier that is triggered by 12(S)‑HETE.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of oncology"
DOI: 10.3892/ijo.2020.4985
Abstract: Metastatic cancer cells cross endothelial barriers and travel through the blood or lymphatic fluid to pre‑metastatic niches, leading to their colonisation. 'S' stereoisomer 12S‑hydroxy‑5Z,8Z,10E,14Z‑eicosatetraenoic acid [12(S)‑HETE] is secreted by a variety of cancer cell types… read more here.
Keywords: sox18 fak; rela sox18; fak; cancer ... See more keywords