Local induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.03.033
Abstract: Lymphangiogenesis occurs in inflammation and wound healing, yet its functional roles in these processes are not fully understood. Consequently, clinically relevant strategies for therapeutic lymphangiogenesis remain underdeveloped, particularly using growth factors. To achieve controlled, local… read more here.
Keywords: lymphangiogenesis; wound healing; fibrin binding; vegf ... See more keywords
Cytokines regulating lymphangiogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2018.04.003
Abstract: Lymphatic vessels are established by differentiation of lymphendothelial progenitors during embryogenesis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing ones is rare in the healthy adult but takes place during pathological conditions such as… read more here.
Keywords: lymphangiogenesis; cytokines regulating; immunology; regulating lymphangiogenesis ... See more keywords
Innate effector cells in angiogenesis and lymphangiogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2018.05.002
Abstract: Angiogenesis and lymphangiogenesis are distinct and complex processes requiring a finely tuned balance between stimulatory and inhibitory signals. During adulthood, angiogenesis and lymphangiogenesis are activated at sites of tumor growth, tissue injury and remodeling, and… read more here.
Keywords: lymphangiogenesis; cells angiogenesis; innate effector; effector cells ... See more keywords
Eplerenone inhibits UUO-induced lymphangiogenesis and cardiac fibrosis by attenuating inflammatory injury.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108759
Abstract: Cardiorenal syndrome (CRS) is the leading cause of death associated with chronic kidney disease (CKD) and end-stage renal disease (ESRD). However, the underlying mechanisms of CRS are still poorly understood. Here, we studied a CKD… read more here.
Keywords: cardiac fibrosis; fibrosis; inflammatory injury; lymphangiogenesis ... See more keywords
Connective tissue growth factor regulates fibrosis-associated renal lymphangiogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Kidney international"
DOI: 10.1016/j.kint.2017.03.029
Abstract: Lymphangiogenesis is correlated with the degree of renal interstitial fibrosis. Pro-fibrotic transforming growth factor β induces VEGF-C production, the main driver of lymphangiogenesis. Connective tissue growth factor (CTGF) is an important determinant of fibrotic tissue remodeling,… read more here.
Keywords: lymphangiogenesis; growth factor; ctgf; fibrosis associated ... See more keywords
Investigating Lymphangiogenesis in a Sacrificially Bioprinted Volumetric Model of Breast Tumor Tissue.
Sign Up to like & getrecommendations! Published in 2020 at "Methods"
DOI: 10.1016/j.ymeth.2020.04.003
Abstract: Lymphatic vessels, as a means to metastasize, are frequently recruited by tumor tissues during their progression. However, reliable in vitro models to dissect the intricate crosstalk between lymphatic vessels and tumors are still in urgent… read more here.
Keywords: lymphangiogenesis; breast tumor; tissue; model ... See more keywords
miR-503-5p inhibits colon cancer tumorigenesis, angiogenesis, and lymphangiogenesis by directly downregulating VEGF-A
Sign Up to like & getrecommendations! Published in 2020 at "Gene Therapy"
DOI: 10.1038/s41434-020-0167-3
Abstract: MicroRNAs (miRNAs) are considered important in the pathogenesis of colon cancer. But the mechanism of their role in colon cancer is still largely unknown. Here, we aimed to explore the function of miR-503-5p in the… read more here.
Keywords: lymphangiogenesis; angiogenesis; mir 503; colon ... See more keywords
Eating your own fat to stay fit: lipophagy sustains lymphangiogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2117513
Abstract: ABSTRACT Lymphatic endothelial cells (LECs) exploit fatty acid oxidation (FAO) to grow and to maintain lymphatic vessel identity through the epigenetic regulation of the essential transcription factor PROX1. In our recent study, we found that… read more here.
Keywords: fat stay; stay fit; lipophagy sustains; lymphangiogenesis ... See more keywords
PS-B12-1: EPLERENONE INHIBITS UUO-INDUCED LYMPHANGIOGENESIS AND CARDIAC FIBROSIS BY ATTENUATING INFLAMMATORY INJURY
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000917492.48464.e4
Abstract: Objective: Cardiorenal syndrome (CRS) is the leading cause of death associated with chronic kidney disease (CKD) and end-stage renal disease (ESRD), however, the underlying mechanism of CKD-induced cardiac injury is incompletely understood. We reported that… read more here.
Keywords: cardiac fibrosis; lymphangiogenesis; uuo induced; injury ... See more keywords
A high-fat diet in the absence of obesity increases lymphangiogenesis by inducing VEGF-C in a murine lymphedema model.
Sign Up to like & getrecommendations! Published in 2022 at "Plastic and reconstructive surgery"
DOI: 10.1097/prs.0000000000010037
Abstract: BACKGROUND Many researchers have attempted to induce lymphangiogenesis for the treatment of lymphedema. However, most previous studies had limited clinical usefulness. A high-fat diet (HFD) increases serum β-hydroxybutyrate (β-OHB) levels, which can stimulate lymphangiogenesis. The… read more here.
Keywords: lymphedema model; lymphangiogenesis; lymphedema; high fat ... See more keywords
TGFBIp mediates lymphatic sprouting in corneal lymphangiogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14633
Abstract: Corneal lymphangiogenesis plays a key role in diverse pathological conditions of the eye. Here, we demonstrate that a versatile extracellular matrix protein, transforming growth factor‐β induced protein (TGFBIp), promotes lymphatic sprouting in corneal lymphangiogenesis. TGFBIp… read more here.
Keywords: lymphangiogenesis; corneal lymphangiogenesis; sprouting corneal; tgfbip ... See more keywords