New reporter zebrafish line unveils heterogeneity among lymphatic endothelial cells during development
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Dynamics"
DOI: 10.1002/dvdy.286
Abstract: In zebrafish, lymphatic endothelial cells (LECs) originate from multiple/several distinct progenitor populations and generate organ‐specific lymphatic vasculatures. Cell fate and tissue specificities were determined using a combination of genetically engineered transgenic lines in which the… read more here.
Keywords: reporter zebrafish; zebrafish line; new reporter; endothelial cells ... See more keywords
A novel method for isolating lymphatic endothelial cells from lymphatic malformations and detecting PIK3CA somatic mutation in these isolated cells
Sign Up to like & getrecommendations! Published in 2020 at "Surgery Today"
DOI: 10.1007/s00595-020-02122-3
Abstract: Purpose Tissue disaggregation and the cell sorting technique by surface markers has played an important role in isolating lymphatic endothelial cells (LECs) from lymphatic malformation (LM). However, this technique may have the drawback of impurities… read more here.
Keywords: novel method; method isolating; method; endothelial cells ... See more keywords
Lymphatic endothelial cells promote T lymphocyte migration into lymph nodes under hyperlipidemic conditions.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.154
Abstract: Lymphatic vessels serve as conduits through which immune cells traffic. Because lymphatic vessels are also involved in lipid transport, their function is vulnerable to abnormal metabolic conditions such as obesity and hyperlipidemia. Exactly how these… read more here.
Keywords: palmitic acid; lymph nodes; migration; endothelial cells ... See more keywords
Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Cell metabolism"
DOI: 10.1016/j.cmet.2021.04.019
Abstract: The lymphatic vasculature plays important roles in the physiology of the organs in which it resides, though a clear mechanistic understanding of how this crosstalk is mediated is lacking. Here, we performed single-cell transcriptional profiling… read more here.
Keywords: neurotensin anti; endothelial cells; lymphatic endothelial; adipose tissue ... See more keywords
Lymphatic endothelial progenitor cells: origins and roles in lymphangiogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2018.04.012
Abstract: How are lymphatic vessels built? What are the sources of progenitor cells employed to construct lymphatic vessels during embryogenesis and in pathological situations? Are lymphatic vessels in different tissues built the same way? These questions… read more here.
Keywords: progenitor cells; cells origins; endothelial progenitor; lymphatic endothelial ... See more keywords
VEGFR‐3 signaling is regulated by a G‐protein activator, activator of G‐protein signaling 8, in lymphatic endothelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.04.007
Abstract: ABSTRACT Vascular endothelial growth factor C (VEGFC) and its cognate receptor VEGFR‐3 play a key role in lymphangiogenesis. We previously reported that an ischemia‐inducible G&bgr;&ggr; signal regulator, activator of G‐protein signaling 8 (AGS8), regulated the… read more here.
Keywords: activator; protein signaling; endothelial cells; lymphatic endothelial ... See more keywords
Migratory dendritic cells acquire and present lymphatic endothelial cell-archived antigens during lymph node contraction
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02247-z
Abstract: Antigens derived from viral infection or vaccination can persist within a host for many weeks after resolution of the infection or vaccine responses. We previously identified lymphatic endothelial cells (LEC) as the repository for this… read more here.
Keywords: migratory dendritic; migratory; archived antigens; dendritic cells ... See more keywords
Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-019-14127-9
Abstract: Lymphatic endothelial cells (LECs) chemoattract naïve T cells and promote their survival in the lymph nodes, and can cross-present antigens to naïve CD8+ T cells to drive their proliferation despite lacking key costimulatory molecules. However,… read more here.
Keywords: cd8 cells; memory cells; lymphatic endothelial; endothelial cells ... See more keywords
Impairment of lymphatic endothelial barrier function by X-ray irradiation
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2019.1562253
Abstract: Abstract Purpose: Although the microvascular system is a significant target for radiation-induced effects, the lymphatic response to radiation has not been extensively investigated. This is one of the first investigations characterizing the lymphatic endothelial response… read more here.
Keywords: irradiation; response; endothelial barrier; lymphatic endothelial ... See more keywords
ELM: A New, Simple, and Economic Assay to Measure Motility of Lymphatic Endothelial Cells
Sign Up to like & getrecommendations! Published in 2017 at "Lymphatic Research and Biology"
DOI: 10.1089/lrb.2016.0032
Abstract: Abstract Background: Relatively few attempts have been made to set up an assay that allows the measurement of lymphatic endothelial cells (LECs) motility. Nowadays, the most widely used methods involve adaptation of the Boyden chamber… read more here.
Keywords: elm assay; biology; endothelial cells; lymphatic endothelial ... See more keywords
Lymphatic Endothelial Cells: Mechanical Stress, Cytokines, Fibrosis, and Age.
Sign Up to like & getrecommendations! Published in 2017 at "Lymphatic research and biology"
DOI: 10.1089/lrb.2017.29025.sr
Abstract: Our comprehension of lymphatic biology, as well as our ability to contemplate therapeutic amelioration of human lymphatic diseases, depends heavily upon insights into the central biology of the lymphatic endothelial cell. In the current issue… read more here.
Keywords: mechanical stress; age; biology; endothelial cells ... See more keywords