Generation and selection of naïve Fab library for parasitic antigen: Anti‐BmSXP antibodies for lymphatic filariasis
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1591
Abstract: Phage display has been applied successfully as a tool for the generation of monoclonal antibodies (mAbs). Naive antibody libraries are unique as they are able to overcome several limitations associated with conventional mAb generation methods… read more here.
Keywords: lymphatic filariasis; bmsxp; fab; generation ... See more keywords
Human filariasis—contributions of the Litomosoides sigmodontis and Acanthocheilonema viteae animal model
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology Research"
DOI: 10.1007/s00436-020-07026-2
Abstract: Filariae are vector-borne parasitic nematodes that are endemic worldwide, in tropical and subtropical regions. Important human filariae spp. include Onchocerca volvulus, Wuchereria bancrofti and Brugia spp., and Loa loa and Mansonella spp. causing onchocerciasis (river… read more here.
Keywords: filariasis; lymphatic filariasis; acanthocheilonema viteae; sigmodontis acanthocheilonema ... See more keywords
Immunoprophylaxis of multi-antigen peptide (MAP) vaccine for human lymphatic filariasis
Sign Up to like & getrecommendations! Published in 2017 at "Immunologic Research"
DOI: 10.1007/s12026-017-8911-5
Abstract: Human lymphatic filariasis, the parasitic disease caused by the filarial nematodes Wuchereria bancrofti, Brugia malayi, and Brugia timori, is ranked as the second most complex clinical condition leading to permanent and long-term disability. The multiple… read more here.
Keywords: vaccine; antigen peptide; human lymphatic; lymphatic filariasis ... See more keywords
High Tregs and systemic IL-10 expressions linked to the absence of sheath antibodies in lymphatic filariasis: implications on the persistence of residual infection.
Sign Up to like & getrecommendations! Published in 2021 at "Immunologic research"
DOI: 10.1007/s12026-021-09175-7
Abstract: The persistence of residual infection is one of the major factors in failure of the Global Programme to Eliminate Lymphatic Filariasis (GPELF). The present study aims to explore the status of sheath antibody and regulatory… read more here.
Keywords: persistence residual; lymphatic filariasis; infection; residual infection ... See more keywords
Screening and evaluation of lymphatic filariasis in immigrants from endemic countries residing in a focus where it is considered eliminated in the Southern Region of Brazil: A risk of reemergence?
Sign Up to like & getrecommendations! Published in 2017 at "Acta tropica"
DOI: 10.1016/j.actatropica.2017.08.010
Abstract: Lymphatic filariasis (LF) has been targeted by the World Health Organization for elimination by the year 2020. However, migration of infected individuals from areas where LF is endemic to areas considered non-endemic or foci for… read more here.
Keywords: filariasis; filariasis immigrants; lymphatic filariasis; screening evaluation ... See more keywords
Disregarding reservoirs of disease vectors: A surveillance paradox in Africa
Sign Up to like & getrecommendations! Published in 2020 at "EClinicalMedicine"
DOI: 10.1016/j.eclinm.2020.100629
Abstract: Vector borne diseases (VBDs) continue to sustain the huge burden of communicable diseases in Africa, as efficient indigenous and invasive vectors expand their range and abundance. Consequently, malaria, lymphatic filariasis, and arboviral diseases, such as… read more here.
Keywords: vector; surveillance; lymphatic filariasis; disease ... See more keywords
Design, expression, and evaluation of novel multiepitope chimeric antigen of Wuchereria bancrofti for the diagnosis of lymphatic filariasis - A structure-based strategy.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106431
Abstract: The Global Program for Elimination Lymphatic Filariasis (GPELF) is in an advanced stage and requires tools for diagnosing infection, assessing transmission and certification. This study was aimed at developing an antibody-based assay using a chiemric… read more here.
Keywords: lymphatic filariasis; antibody; multiepitope; antigen ... See more keywords
The Current Status of Molecular Xenomonitoring for Lymphatic Filariasis and Onchocerciasis.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in parasitology"
DOI: 10.1016/j.pt.2017.06.008
Abstract: The capacity of vector insect surveillance to provide estimates of pathogen prevalence and transmission potential has long been recognized within the global communities tasked with eliminating lymphatic filariasis (LF), the underlying cause of elephantiasis and… read more here.
Keywords: status molecular; lymphatic filariasis; molecular xenomonitoring; current status ... See more keywords
Evaluating the Evidence for Lymphatic Filariasis Elimination
Sign Up to like & getrecommendations! Published in 2019 at "Trends in Parasitology"
DOI: 10.1016/j.pt.2019.08.003
Abstract: In the global drive for elimination of lymphatic filariasis (LF), 15 countries have achieved validation of elimination as a public health problem (EPHP). Recent empirical evidence has demonstrated that EPHP does not always lead to… read more here.
Keywords: lymphatic filariasis; evaluating evidence; evidence lymphatic; evidence ... See more keywords
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-018-07826-2
Abstract: Nematodes causing lymphatic filariasis and onchocerciasis rely on their bacterial endosymbiont, Wolbachia, for survival and fecundity, making Wolbachia a promising therapeutic target. Here we perform a high-throughput screen of AstraZeneca’s 1.3 million in-house compound library… read more here.
Keywords: industrial scale; anti wolbachia; throughput; lymphatic filariasis ... See more keywords
Comparison of Staging Systems to Assess Lymphedema Caused by Cancer Therapies, Lymphatic Filariasis, and Podoconiosis
Sign Up to like & getrecommendations! Published in 2019 at "Lymphatic Research and Biology"
DOI: 10.1089/lrb.2018.0063
Abstract: Abstract Background: Lymphedema is a disease of the skin and subcutaneous tissue resulting from a disturbance in lymph flow. Anyone can be affected, and causes include cancer therapy when lymph nodes are removed or irradiated,… read more here.
Keywords: filariasis podoconiosis; lymphatic filariasis; staging systems; lymphedema ... See more keywords