Promoting intestinal lymphatic transport targets a liver‐X receptor (LXR) agonist (WAY‐252,623) to lymphocytes and enhances immunomodulation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2019.01.002
Abstract: ABSTRACT Lymphocytes play a central role in the pathology of a range of chronic conditions such as autoimmune disease, transplant rejection, leukemia, lymphoma HIV/AIDs and cardiometabolic diseases such as atherosclerosis. Current treatments for lymphocyte‐associated conditions… read more here.
Keywords: way 252; liver receptor; lymphatic transport; 252 623 ... See more keywords
The impact of conjugation position and linker chemistry on the lymphatic transport of a series of glyceride and phospholipid mimetic prodrugs.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.10.021
Abstract: Drug delivery to the lymphatic system is gaining increasing attention, particularly in fields such as immunotherapy where drug access to lymphocytes is central to activity. We have previously described a prodrug strategy that facilitates the… read more here.
Keywords: mimetic prodrugs; glyceride phospholipid; position; chemistry ... See more keywords
Mechanistic Oral Absorption Modeling of Halofantrine: Exploring the Role of Intestinal Lymphatic Transport.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.12.023
Abstract: Absorption via the intestinal lymphatic system is known to be important for some highly lipophilic compounds, and can be associated with unique pharmacokinetic properties due to evasion of hepatic first-pass metabolism. This work aimed to… read more here.
Keywords: absorption; oral absorption; model; lymphatic transport ... See more keywords
Increasing Linker Chain Length and Intestinal Stability Enhances Lymphatic Transport and Lymph Node Exposure of Triglyceride Mimetic Prodrugs of a Model Immunomodulator Mycophenolic Acid.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00099
Abstract: Targeted delivery of immunomodulators to the lymphatic system has the potential to enhance therapeutic efficacy by increasing colocalization of drugs with immune targets such as lymphocytes. A triglyceride (TG)-mimetic prodrug strategy has been recently shown… read more here.
Keywords: mimetic prodrugs; lymph; lymphatic transport; transport ... See more keywords
Validity of cycloheximide chylomicron flow blocking method for the evaluation of lymphatic transport of drugs.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of pharmacology"
DOI: 10.1111/bph.15644
Abstract: BACKGROUND AND PURPOSE Lymphatic transport of drugs after oral administration is an important mechanism for absorption of highly lipophilic compounds. Direct measurement in lymph duct cannulated animals is the gold standard method, but non-invasive cycloheximide… read more here.
Keywords: cycloheximide chylomicron; transport; chylomicron flow; lymphatic transport ... See more keywords
Quantitative measurement of lymphatic function in mice by noninvasive near-infrared imaging of a peripheral vein.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.90861
Abstract: Optical imaging methods have been developed to measure lymphatic function in skin; however, the lymphatic system of many organs is not accessible to this technology. Since lymphatic transport of macromolecules from any organ proceeds to… read more here.
Keywords: near infrared; lymphatic function; lymphatic transport; blood ... See more keywords
Lymphatic Transport Efficiency Determines Metastatic Potential of Cutaneous Melanoma
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.01607
Abstract: Background In staging patients with clinical stage I-II melanoma, the sentinel lymph node (SLN) is the most important prognostic indicator; however, the false negative rate of SLN biopsy (SLNB) is 15%. Methods Nine patients with… read more here.
Keywords: melanoma; efficiency determines; lymphatic transport; transport efficiency ... See more keywords