Splicing variant profiles and single nucleotide polymorphisms of the glucocorticoid receptor gene in relation to glucocorticoid sensitivity of B‐cell precursor acute lymphoblastic leukaemia
Sign Up to like & getrecommendations! Published in 2018 at "Hematological Oncology"
DOI: 10.1002/hon.2471
Abstract: Glucocorticoid (GC) shows antileukaemic activity via binding to the GC receptor (GR). The human GR gene has 4 splicing variants besides the functional isoform GRα, but their significance in GC sensitivity of acute lymphoblastic leukaemia… read more here.
Keywords: single nucleotide; sensitivity; lymphoblastic leukaemia; acute lymphoblastic ... See more keywords
[Tocilizumab in a child with acute lymphoblastic leukaemia and COVID-19-related cytokine release syndrome].
Sign Up to like & getrecommendations! Published in 2020 at "Anales de pediatria"
DOI: 10.1016/j.anpedi.2020.05.002
Abstract: As of May 1, 2020, coronavirus disease caused by infection by SARS-CoV-2 (COVID-19) has affected over 3 181 000 people worldwide and caused more than 220 000 deaths. Around 1% of cases occur in children… read more here.
Keywords: tocilizumab child; child acute; lymphoblastic leukaemia; covid ... See more keywords
Insights into defective serological memory after acute lymphoblastic leukaemia treatment: The role of the plasma cell survival niche, memory B-cells and gut microbiota in vaccine responses.
Sign Up to like & getrecommendations! Published in 2018 at "Blood reviews"
DOI: 10.1016/j.blre.2017.08.009
Abstract: Acute lymphoblastic leukaemia (ALL) is the most common type of cancer in children, accounting for approximately 25% of childhood cancer cases. As a result of effective treatments over the past decades, paediatric ALL mortality has… read more here.
Keywords: lymphoblastic leukaemia; acute lymphoblastic; serological memory; gut microbiota ... See more keywords
Enrichment of atypical hyperdiploidy and IKZF1 deletions detected by SNP-microarray in high-risk Australian AIEOP-BFM B-cell acute lymphoblastic leukaemia cohort.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2020.01.051
Abstract: Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy with the majority of patients being classified as B-cell lineage (B-ALL). The sub-classification of B-ALL is based on genomic architecture. Recent studies have demonstrated the… read more here.
Keywords: risk; high risk; lymphoblastic leukaemia; cohort ... See more keywords
Successful toxicity reduction during delayed intensification in the non-high-risk arm of Malaysia-Singapore Acute Lymphoblastic Leukaemia 2010 study.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of cancer"
DOI: 10.1016/j.ejca.2020.10.010
Abstract: In non-high-risk (non-HR) patients, the Malaysia-Singapore Acute Lymphoblastic Leukaemia 2003 (MS2003) study achieved good outcomes. However, its delayed-intensification (DI) phase, comprising repeated blocks of protocol III (2003-PIII), was toxic and caused significant treatment delays. The… read more here.
Keywords: risk; study; lymphoblastic leukaemia; toxicity ... See more keywords
Subleukaemic T-Lymphoblastic Leukaemia in a Horse.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of comparative pathology"
DOI: 10.1016/j.jcpa.2021.08.002
Abstract: A 20-year-old Dutch Warmblood gelding was referred with clinical signs of anorexia, weight loss, intermittent fever, cough, subcutaneous oedema and exercise intolerance. Haematological examination revealed the presence of blast cells, decreased lymphocytes, mild thrombocytopenia and… read more here.
Keywords: lymphoblastic leukaemia; subleukaemic lymphoblastic; leukaemia horse; neoplastic cells ... See more keywords
Extensive intracranial haemorrhage as a complication of acute lymphoblastic leukaemia with hyperleukocytosis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2019.03.056
Abstract: We report a rare case of distinctive extensive punctate intracranial haemorrhage associated with acute lymphoblastic leukaemia with hyperleukocytosis. A 7-year-old girl presented with hyperleukocytosis (white cell count 788.7 × 109/L; 94% peripheral blasts) and laboratory tumour lysis… read more here.
Keywords: lymphoblastic leukaemia; intracranial haemorrhage; acute lymphoblastic; hyperleukocytosis ... See more keywords
Evaluation of coagulopathy before and during induction chemotherapy for acute lymphoblastic leukaemia, including assessment of global clotting tests
Sign Up to like & getrecommendations! Published in 2017 at "Blood Cancer Journal"
DOI: 10.1038/bcj.2017.54
Abstract: Evaluation of coagulopathy before and during induction chemotherapy for acute lymphoblastic leukaemia, including assessment of global clotting tests read more here.
Keywords: coagulopathy induction; chemotherapy acute; lymphoblastic leukaemia; evaluation coagulopathy ... See more keywords
A systematic review and meta-analysis of the association between childhood infections and the risk of childhood acute lymphoblastic leukaemia
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Cancer"
DOI: 10.1038/bjc.2017.360
Abstract: Background:To determine whether childhood infections were associated with the development of childhood acute lymphoblastic leukaemia (ALL).Methods:We included studies that assessed any infection in childhood prior to the diagnosis of ALL in children aged 0–19 years… read more here.
Keywords: childhood acute; childhood; analysis; childhood infections ... See more keywords
Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13069-6
Abstract: There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with four GWAS… read more here.
Keywords: risk; cell acute; lymphoblastic leukaemia; acute lymphoblastic ... See more keywords
Converging genetic and epigenetic drivers of paediatric acute lymphoblastic leukaemia identified by an information-theoretic analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Nature biomedical engineering"
DOI: 10.1038/s41551-021-00703-2
Abstract: In cancer, linking epigenetic alterations to drivers of transformation has been difficult, in part because DNA methylation analyses must capture epigenetic variability, which is central to tumour heterogeneity and tumour plasticity. Here, by conducting a… read more here.
Keywords: methylation; information; paediatric acute; analysis ... See more keywords