Myricetin‐induced oxidative stress suppresses murine T lymphocyte activation
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biology International"
DOI: 10.1002/cbin.10977
Abstract: A number of polyphenolic compounds present in fruits and vegetables have the capacity to modulate immune responses; however, the impact of the common plant‐derived flavonoid myricetin on T lymphocyte function has not been investigated. We… read more here.
Keywords: lymphocyte activation; induced oxidative; cell; myricetin ... See more keywords
Overexpression of genes involved in lymphocyte activation and regulation are associated with reduced CRM-derived cardiac remodelling after STEMI.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107490
Abstract: AIMS Lymphopenia after ST-segment elevation myocardial infarction (STEMI) correlates with deleterious cardiac consequences and worse prognosis. An in-depth examination of genes implicated in lymphocyte proliferation, activation and regulation and their association with short- and long-term… read more here.
Keywords: lymphocyte activation; expression; activation; function ... See more keywords
Implant delivering hydroxychloroquine attenuates vaginal T lymphocyte activation and inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2018.03.010
Abstract: &NA; Evidence suggests that women who are naturally resistant to HIV infection exhibit low baseline immune activation at the female genital tract (FGT). This “immune quiescent” state is associated with lower expression of T‐cell activation… read more here.
Keywords: hiv infection; activation inflammation; vaginal lymphocyte; lymphocyte activation ... See more keywords
Discovery of First-in-Class Small Molecule Inhibitors of Lymphocyte Activation Gene 3 (LAG-3).
Sign Up to like & getrecommendations! Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.3c00054
Abstract: Lymphocyte activation gene 3 (LAG-3) is a negative immune checkpoint that plays a key role in downregulating the immune response to cancer. Inhibition of LAG-3 interactions allows T cells to regain cytotoxic activity and reduce… read more here.
Keywords: activation gene; lymphocyte activation; lag; gene lag ... See more keywords
Lymphocyte activation gene 3 (Lag3) expression is increased in prion infections but does not modify disease progression
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32712-8
Abstract: Prion diseases, Alzheimer’s disease and Parkinson’s disease (PD) are fatal degenerative disorders that share common neuropathological and biochemical features, including the aggregation of pathological protein conformers. Lymphocyte activation gene 3 (Lag3, also known as CD223)… read more here.
Keywords: gene lag3; lymphocyte activation; prion; activation gene ... See more keywords
On certain two‐signal perspectives of lymphocyte activation and inactivation, thymic G‐quadruplexes, and the role of aggregation in self/not‐self discrimination
Sign Up to like & getrecommendations! Published in 2019 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12797
Abstract: Distinctive “two signal” paths in immunology, taken by researchers with different academic backgrounds, seem to have both contained facets of the truth. Having been influenced by education at a medical school where Almroth Wright’s early… read more here.
Keywords: certain two; lymphocyte activation; signal perspectives; perspectives lymphocyte ... See more keywords
Tempering lymphocyte activation
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.369.6501.264-w
Abstract: Immunodeficiency Diagnosis and treatment of inborn errors in immunity remain a challenge. Salzer et al. studied two siblings who were hospitalized for recurrent pediatric infections. Exome sequencing and functional analyses helped to identify homozygous loss-of-function… read more here.
Keywords: cell; tempering lymphocyte; lymphocyte activation; hem1 ... See more keywords
Gene of the month: lymphocyte-activation gene 3 (LAG-3)
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2021-207517
Abstract: Lymphocyte-activation gene 3 (LAG-3) is a coreceptor found on activated T-lymphocytes activated B-lymphocytes and natural killer (NK) cells. It is closely related to CD4 where it shares multiple common and divergent features. It contains specific… read more here.
Keywords: gene lag; lymphocyte activation; activation gene; lag ... See more keywords
Eftilagimod alpha, a soluble lymphocyte activation gene-3 (LAG-3) protein plus pembrolizumab in patients with metastatic melanoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-001681
Abstract: Background To evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of eftilagimod alpha (efti), a soluble lymphocyte activation gene-3 protein, in combination with the programmed cell death-1 (PD-1) antagonist pembrolizumab. Methods The study was divided into… read more here.
Keywords: part; eftilagimod alpha; lymphocyte activation; patients metastatic ... See more keywords
Decrease of Hyaluronidase Activity and Suppression of Mouse CD4+ T Lymphocyte Activation by Tomato Juice Saponin Esculeoside B, and Its Sapogenol Esculeogenin B
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12040579
Abstract: (1) Background: A naturally occurring glycoside, esculeoside B (EsB), has been identified as a major component in juice or canned tomato. We reported how EsB ameliorated mice experimental atopic dermatitis by a decrease in serum… read more here.
Keywords: hyaluronidase activity; lymphocyte activation; activity; cd4 lymphocyte ... See more keywords