Associations between cytotoxic T-lymphocyte-associated antigen 4 gene polymorphisms and diabetes mellitus: a meta-analysis of 76 case–control studies
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DOI: 10.1042/bsr20190309
Abstract: Background: Several genetic association studies already investigated potential roles of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms in diabetes mellitus (DM), with inconsistent results. Therefore, we performed this meta-analysis to better assess the relationship between… read more here.
Keywords: cytotoxic lymphocyte; gene polymorphisms; associated antigen; diabetes mellitus ... See more keywords
Cytotoxic T-lymphocyte-associated protein 4 gene polymorphism is related to rheumatoid arthritis in Egyptian population
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DOI: 10.1080/13813455.2016.1230135
Abstract: Abstract Context: Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a CD28-family receptor expressed on T-cells which suppresses T cell proliferation. CTLA-4 -318C/T polymorphism is involved in regulation of CTLA-4 expression. Objective: The study aimed to investigate… read more here.
Keywords: associated protein; polymorphism; ctla; cytotoxic lymphocyte ... See more keywords
A family with cytotoxic T-lymphocyte-associated protein 4 haploinsufficiency presenting with aplastic anaemia
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DOI: 10.1136/bcr-2021-247653
Abstract: Acquired aplastic anaemia is a rare disease, and occurrence in more than one member of the same family is uncommon. With this case report, we wish to highlight the importance of searching for an underlying… read more here.
Keywords: lymphocyte associated; haploinsufficiency; cytotoxic lymphocyte; aplastic anaemia ... See more keywords
Cytotoxic T lymphocyte-associated antigen 4 rs231775 polymorphism and osteosarcoma.
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DOI: 10.4149/neo_2017_218
Abstract: Systematic reviews on osteosarcoma have concluded that CTLA4 rs231775 AA genotype influences risk for the disease in the Chinese population. Remarkably, rs231775 shows different frequencies in different human populations. Therefore, it would be interesting to… read more here.
Keywords: associated antigen; cytotoxic lymphocyte; rs231775 genotype; ctla4 rs231775 ... See more keywords
Distribution of Cytotoxic T Lymphocyte-Associated Antigen-4 Promoter Polymorphisms in Taiwanese Patients with Type 2 Diabetes Mellitus
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DOI: 10.7150/ijms.23097
Abstract: Type 2 diabetes mellitus (T2DM) is associated with chronic inflammation, suggesting the metabolic abnormalities are originated from or exacerbated by cytokine overproduction. Cytokines and counter-regulatory molecules are crucial in keeping the balance of immune responses… read more here.
Keywords: associated antigen; cytotoxic lymphocyte; type diabetes; diabetes mellitus ... See more keywords