Functional and genetic testing in adults with HLH reveals an inflammatory profile rather than a cytotoxicity defect
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DOI: 10.1182/blood.2019003664
Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory condition. Primary HLH occurs early in life as a result of monogenic biallelic mutations affecting lymphocyte cytotoxicity. Secondary HLH occurs mostly in adults secondary to infection, lymphoma, or… read more here.
Keywords: cell cytotoxicity; cytotoxicity; secondary hlh; lymphocyte cytotoxicity ... See more keywords