Exploring the significance of PAK1 through chromosome conformation signatures in ibrutinib‐resistant chronic lymphocytic leukaemia
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DOI: 10.1002/1878-0261.13281
Abstract: Ibrutinib exerts promising anticancer effects in chronic lymphocytic leukaemia (CLL). However, acquired resistance occurs during treatment, necessitating the exploration of underlying mechanisms. Although three‐dimensional genome organization has been identified as a major player in the… read more here.
Keywords: pak1; ibrutinib resistant; chronic lymphocytic; chromosome conformation ... See more keywords
Idelalisib plus rituximab is effective in systemic AL amyloidosis secondary to chronic lymphocytic leukaemia
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DOI: 10.1002/hon.2480
Abstract: Light chain amyloidosis is characterized by the progressive deposition of immunoglobulin light chains into the extracellular tissue, leading to organ dysfunction. Usually, it is associated with an underlying clonal plasma cell dyscrasia and rarely with… read more here.
Keywords: idelalisib; lymphocytic leukaemia; light; amyloidosis ... See more keywords
SUBCUTANEOUS IMMUNOGLOBULINS IN CHRONIC LYMPHOCYTIC LEUKAEMIA WITH SECONDARY ANTIBODY DEFICIENCY. A MONOCENTRIC EXPERIENCE DURING COVID-19 PANDEMICS.
Sign Up to like & getrecommendations! Published in 2022 at "Hematological oncology"
DOI: 10.1002/hon.2966
Abstract: Secondary antibody deficiency (SAD) is a frequent manifestation of chronic lymphocytic leukaemia (CLL) that increases the risk of infections. However, no formal guideline are available regarding the eligibility for prophylaxis or the delivery method, dosage,… read more here.
Keywords: cll; secondary antibody; covid; antibody deficiency ... See more keywords
Central nervous system localisation of chronic lymphocytic leukaemia, description of two very distinct cases and a review of the literature
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DOI: 10.1007/s00277-018-3329-2
Abstract: Central nervous system (CNS) localisation of chronic lymphocytic leukaemia (CLL) can induce various neurological symptoms. Unfamiliarity with this manifestation causes diagnostic delay. We present two cases of leptomeningeal CLL. These cases and our literature review… read more here.
Keywords: nervous system; central nervous; localisation; lymphocytic leukaemia ... See more keywords
Ethnic and geographic diversity of chronic lymphocytic leukaemia
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DOI: 10.1038/s41375-020-01057-5
Abstract: East Asians, Asian Indians and Amerindians have a five to ten-fold lower age-adjusted incidence rate (AAIR) of chronic lymphocytic leukaemia (CLL) compared with persons of predominately European descent. The data we review suggest a genetic… read more here.
Keywords: geographic diversity; cll; ethnic geographic; lymphocytic leukaemia ... See more keywords
Chromosomal alterations among age-related haematopoietic clones in Japan
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DOI: 10.1038/s41586-020-2426-2
Abstract: The extent to which the biology of oncogenesis and ageing are shaped by factors that distinguish human populations is unknown. Haematopoietic clones with acquired mutations become common with advancing age and can lead to blood… read more here.
Keywords: haematopoietic clones; age; lymphocytic leukaemia; chronic lymphocytic ... See more keywords
Cardiac Richter's syndrome: a rare case of chronic lymphocytic leukaemia transformation.
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DOI: 10.1093/eurheartj/ehad184
Abstract: A 71–year–old woman with chronic lymphocytic leukaemia (CLL) presented to our Cardiology clinic complaining of recent–onset chest pain and dysphonia. Physical examination and ECG were normal. A blood test revealed high levels of high–sensitivity troponin… read more here.
Keywords: cll; richter syndrome; lymphocytic leukaemia; chronic lymphocytic ... See more keywords
Microtubule‐associated protein 1A/1B‐light chain 3 (LC3) ‘decorates’ intracytoplasmic inclusions in a patient with chronic lymphocytic leukaemia
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DOI: 10.1111/bjh.14893
Abstract: A 77-year-old woman, diagnosed nine years previously with chronic lymphocytic leukaemia (CLL) Rai stage I, was referred to our hospital with disease progression (night sweats, weight loss and organomegaly). Her peripheral blood count showed leucocytosis… read more here.
Keywords: light chain; lymphocytic leukaemia; intracytoplasmic inclusions; chronic lymphocytic ... See more keywords
Efficacy of venetoclax monotherapy in patients with relapsed chronic lymphocytic leukaemia in the post‐BCR inhibitor setting: a UK wide analysis
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.15802
Abstract: Venetoclax is a BCL2 inhibitor with activity in relapsed/refractory (R/R) chronic lymphocytic leukaemia (CLL). We conducted a multi‐centre retrospective analysis of 105 R/R CLL patients who received venetoclax pre‐National Health Service commissioning. The median age… read more here.
Keywords: inhibitor; analysis; lymphocytic leukaemia; chronic lymphocytic ... See more keywords
Practical management of tumour lysis syndrome in venetoclax‐treated patients with chronic lymphocytic leukaemia
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DOI: 10.1111/bjh.16345
Abstract: The treatment landscape in relapsed/refractory chronic lymphocytic leukaemia (CLL) has rapidly evolved over the past five years, with one such emergent treatment being the BCL2 inhibitor, venetoclax. This oral treatment has demonstrated significant clinical advantages… read more here.
Keywords: lysis syndrome; tumour lysis; treatment; lymphocytic leukaemia ... See more keywords
Redefining the prognostic likelihood of chronic lymphocytic leukaemia patients with borderline percentage of immunoglobulin variable heavy chain region mutations
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DOI: 10.1111/bjh.16434
Abstract: In chronic lymphocytic leukaemia (CLL), caution is warranted regarding the clinical implications of immunoglobulin variable heavy chain region (IGHV) rearrangements with a ‘borderline’ (BL) percentage of mutations (i.e. 97–97·9% IGHV identity). We analysed the IGHV… read more here.
Keywords: cll; variable heavy; heavy chain; immunoglobulin variable ... See more keywords