DACH1 DOWNREGULATION DELINEATE A LYMPHOID PRIMED PROGENITOR (LPP) POPULATION WITHIN THE MPP4 CLUSTER
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.448
Abstract: Classical models of haematopoiesis dictate that a single hematopoietic stem cell (HSC) with self-renewal capacity can give rise to all the hematopoietic lineage through subsequent division and loss of potential. This loss of potential is… read more here.
Keywords: primed progenitor; progenitor; dach1; mpp4 cluster ... See more keywords
Group 1 innate lymphoid-cell-derived interferon-γ maintains anti-viral vigilance in the mucosal epithelium.
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2020.12.004
Abstract: The oropharyngeal mucosa serves as a perpetual pathogen entry point and a critical site for viral replication and spread. Here, we demonstrate that type 1 innate lymphoid cells (ILC1s) were the major immune force providing… read more here.
Keywords: cell derived; group innate; mucosal; innate lymphoid ... See more keywords
Innate Lymphoid Cell Regulation: Meeting the Long-Lost Cousin.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in immunology"
DOI: 10.1016/j.it.2017.09.003
Abstract: Innate lymphoid cells (ILCs) play critical roles in immune homeostasis and immunity to pathogens. Increasing evidence implicates dysregulated ILC responses as drivers of disease pathogenesis in multiple inflammatory disorders. A recent study reveals how inflammatory… read more here.
Keywords: innate lymphoid; regulation meeting; lymphoid cell; cell regulation ... See more keywords
IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00235-x
Abstract: Group 3 innate lymphoid cells (ILC3) promote lymphoid organogenesis and potentiate immune responses against bacterial infection. However, how ILC3 cells are developed and maintained is still unclear. Here, we show that carboxypeptidase CCP2 is highly… read more here.
Keywords: group; factor sall3; innate lymphoid; transcription factor ... See more keywords
Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-18283-0
Abstract: A common helper-like innate lymphoid precursor (CHILP) restricted to the innate lymphoid cells (ILC) lineage has been recently characterized. While specific requirements of transcription factors for CHILPs development has been partially described, their ability to… read more here.
Keywords: flt3l levels; bona fide; innate lymphoid; lymphoid ... See more keywords
Retinoic acid receptor activity is required for the maintenance of type 1 innate lymphoid cells.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac057
Abstract: Group 1 innate lymphoid cells (G1-ILCs) are innate immune effectors critical for the response to intracellular pathogens and tumors. G1-ILCs comprise circulating natural killer (NK) cells and tissue-resident type 1 ILCs (ILC1s). ILC1s mainly reside… read more here.
Keywords: lymphoid; ilc1s; retinoic acid; innate lymphoid ... See more keywords
Trained ILC3 responses promote intestinal defense
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.aaz8777
Abstract: Group 3 innate lymphoid cells (ILC3s) are innate immune effectors that contribute to host defense. Whether ILC3 functions are stably modified after pathogen encounter is unknown. Here, we assess the impact of a time-restricted enterobacterial… read more here.
Keywords: lymphoid; long term; trained ilc3; defense ... See more keywords
Abstract 4655: The prognostic significance of a 12-chemokine tertiary lymphoid structure (TLS) gene signature in uveal melanoma (UM)
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4655
Abstract: Introduction Lymphoid aggregates are commonly associated with better prognosis and enhanced response to immune modulators in several cancers. Considering the immune-privileged status of the eye we sought to investigate the immune, genomic and prognostic significance… read more here.
Keywords: lymphoid; chemokine; gep high; signature ... See more keywords
Cyclin D1 overexpression induces global transcriptional downregulation in lymphoid neoplasms
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci96520
Abstract: Cyclin D1 is an oncogene frequently overexpressed in human cancers that has a dual function as cell cycle and transcriptional regulator, although the latter is widely unexplored. Here, we investigated the transcriptional role of cyclin… read more here.
Keywords: overexpression; global transcriptional; cyclin overexpression; cyclin ... See more keywords
Micronodular Thymic Carcinoma with Lymphoid Stroma: A Case Report.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of surgical pathology"
DOI: 10.1177/10668969221133357
Abstract: Background. Micronodular thymic carcinoma (MTC) with lymphoid hyperplasia is believed to be the malignant counterpart of micronodular thymoma (MT) with lymphoid hyperplasia. Since MT and MTC share a similar morphology, MTC is considered a malignant… read more here.
Keywords: lymphoid; mtc; micronodular thymic; thymic carcinoma ... See more keywords
Caveolin-1 is dispensable for early lymphoid development, but plays a role in the maintenance of the mature splenic microenvironment
Sign Up to like & getrecommendations! Published in 2018 at "BMC Research Notes"
DOI: 10.1186/s13104-018-3583-3
Abstract: ObjectiveCaveolin-1 (CAV1) is known for its role as both a tumor suppressor and an oncogene, harboring a highly context-dependent role within a myriad of malignancies and cell types. In an immunological context, dysregulation of CAV1… read more here.
Keywords: cav1 cav1; follicle; cav1; role ... See more keywords